便秘型肠易激综合征是一种以腹痛或腹部不适伴大便排出困难、排便周期延长为主要症状且常伴随焦虑、抑郁等精神症状的胃肠功能紊乱性疾病。促分泌剂可被用来治疗便秘型肠易激综合征，治疗便秘的同时也能够缓解腹痛。促分泌剂目前主要包括3类：氯离子通道激活剂、鸟苷酸环化酶C激活剂、强效小分子钠/氢交换体3抑制剂。总结了促分泌剂治疗便秘型肠易激综合征的作用机制、疗效和安全性，以期为临床应用提供参考。

Constipation-predominant irritable bowel syndrome is a disorder of gastrointestinal function, which is characterized by abdominal pain or abdominal discomfort with difficulty defecation, prolonged defecation time interval, and mental symptoms such as anxiety and depression. Secretagogues can be used to treat constipation-predominant irritable bowel syndrome, which can alleviate abdominal pain while treating constipation. There are currently three main types of secretagogues: chloride channel activators, guanylate cyclase C activators, and potent small molecule sodium/hydrogen exchanger 3 inhibitors. This article summarizes the mechanism, efficacy, and safety of secretagogues in treatment of constipation-predominant irritable bowel syndrome, in order to provide reference for clinical application.

R975

四川省中医药管理局科学技术研究专项（2018LC020）