糖尿病肾病是2型糖尿病的主要并发症之一，是造成终末期肾病和肾功能衰竭患者死亡的主要原因。虎杖苷是从虎杖中提取的活性成分，可通过减轻肾组织炎性损伤、降低氧化应激反应、延缓肾组织纤维化、阻止肾组织细胞凋亡、降低血糖发挥防治糖尿病肾病的作用。总结了虎杖苷用于糖尿病肾病的研究进展，分析了其作用机制，为虎杖苷治疗糖尿病肾病的临床研究提供依据。

Diabetes nephropathy is one of the major complications of type 2 diabetes, and the main cause of death in patients with end-stage renal disease and renal failure. Polydatin is an active ingredient extracted from Polygoni Cuspidati Rhizoma, which can play a role in preventing and treating diabetes nephropathy by reducing inflammatory damage of renal tissue, reducing oxidative stress response, delaying renal tissue fibrosis, preventing renal tissue cells apoptosis, and reducing blood sugar. This article summarized the research progress of polydatin in treatment of diabetes nephropathy, analyzed its mechanism of action, and provided a basis for the clinical study of polydatin in treatment of diabetes nephropathy.

R285

北京慢性病防治与健康教育科研项目（BJMB0012022028001）