目的 探讨肿痛安胶囊联合更昔洛韦片治疗儿童疱疹性口腔炎的临床疗效。方法 选取2021年9月—2024年8月天津市泰达医院收治的疱疹性口腔炎患儿共计86例，按随机数字表法将所有患儿分为对照组和治疗组，每组各43例。对照组口服更昔洛韦片，5 mg/kg，每日分3次服用。治疗组在对照组基础上外用肿痛安胶囊，3次/d，每次将1粒胶囊的药粉敷于患处，至少保持1 h。两组持续治疗14 d。比较两组患儿的临床疗效、症状消失情况、生活质量、免疫球蛋白。结果 治疗组的总有效率为95.35%，对照组的总有效率为81.40%，组间差异明显（P＜0.05）。治疗组退热时间、止痛时间、疱疹消失时间、溃疡消失时间均短于对照组（P＜0.05）。治疗后，两组的儿童皮肤病生活质量指数（CDLQI）评分均降低（P＜0.05），且治疗组的CDLQI评分低于对照组著（P＜0.05）。治疗后，两组IgA、IgM、IgE均明显提高（P＜0.05），治疗组患儿的IgA、IgM、IgE比对照组更高（P＜0.05）。结论 肿痛安胶囊联合更昔洛韦片可提高疱疹性口腔炎的疗效，改善临床症状和免疫球蛋白水平，提高生活质量。

Objective To explore the clinical efficacy of the combination of Tongzhong'an Capsules and Ganciclovir Tablets in treatment of pediatric herpetic stomatitis.Methods 86 Children with herpetic stomatitis admitted to Tianjin Teda Hospital from September 2021 to August 2024 were selected and divided into control group and treatment group according to the random number table method, with 43 cases in each group. The control group patients took Ganciclovir Tablets at a dose of 5 mg/kg, divided into three doses daily. On the basis of the control group, the treatment group was treated with external application of Zhongtong'an Capsules, 3 times daily, apply 1 capsule of powder to the affected area each time, and maintained for at least 1 h. Two groups received continuous treatment for 14 d. The clinical efficacy, symptom disappearance, quality of life, and immunoglobulin levels were compared between two groups. Results The total effective rate of the treatment group (95.35%) was higher than 81.40% of the control group, and the difference between the groups was significant (P < 0.05). The fever reduction time, pain relief time, herpes disappearance time, and ulcer disappearance time of the treatment group were all shorter than those of the control group (P < 0.05). CDLQI scores of both groups was decreased (P < 0.05), and CDLQI scores of the treatment group was lower than those of the control group (P < 0.05). IgA, IgM, and IgE in both groups were increased after treatment (P < 0.05), and these indexes in the treatment group were higher than those of the control group (P < 0.05). Conclusion The combination of Zhongtong'an Capsules and Ganciclovir Tablets can improve the efficacy, improve clinical symptoms and immunoglobulin levels, and enhance quality of life.

R985;R988.2