目的 分析裸花紫珠颗粒与西咪替丁注射液联合治疗上消化道出血的疗效。方法 取皖南医学院附属太和医院于2022年6月—2023年6月收治的86例上消化道出血患者，根据随机信封法将患者分为对照组和治疗组，各43例。对照组缓慢静脉滴注西咪替丁注射液，取2 mL西咪替丁注射液使用5%葡萄糖注射液250 mL稀释，每8 h一次；治疗组在对照组基础上口服裸花紫珠颗粒，1袋/次，4次/d。两组均治疗3 d。比较两组临床疗效、再出血率、临床症状改善时间、凝血功能指标和血常规指标。结果 治疗组的总有效率显著高于对照组，再出血率低于对照组（P＜0.05）。治疗组止血时间、隐血转阴时间、呕血消失时间、腹痛缓解时间均短于对照组（P＜0.05）。治疗后，两组活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶时间（TT）、纤维蛋白原（FIB）显著降低（P＜0.05），且治疗组患者APTT、PT、TT、FIB低于对照组（P＜0.05）。治疗后，两组血红蛋白（Hb）、红细胞计数（RBC）、血细胞比容（HCT）水平显著升高（P＜0.05），且治疗组Hb、RBC、HCT高于对照组（P＜0.05）。结论 裸花紫珠颗粒联合西咪替丁注射液治疗上消化道出血的临床疗效更佳，在改善凝血功能、提高止血效果、降低再出血率方面具有显著优势。

Objective To explore the curative effect of Luohuazizhu Granules combined with Cimetidine Injection in treatment of upper gastrointestinal bleeding. Methods 86 Patients with upper gastrointestinal bleeding admitted to Taihe Hospital Affiliated to South Anhui Medical College from June 2022 to June 2023 were selected as the study subjects. Patients were divided into control and treatment groups according to the randomized envelope method, and each group had 43 patients. The control group was given intravenous infusion of Cimetidine Injection, and 2 mL Cimetidine Injection was diluted with 250 mL 5% glucose injection before intravenous infusion, once every 8 h. The treatment group were po administered with Luohuazizhu Granules based on control group, 1 bag/time, 4 times daily. Both groups were treated for 3 d. The clinical efficacy, rebleeding rate, improvement time of clinical symptoms, coagulation function indicators, and blood routine indicators between two groups were compared. Results After treatment, the total effective rate of the treatment group was significantly higher than that of the control group, but the rebleeding rate was lower than that of the control group (P < 0.05). The hemostasis time, occult blood turning negative time, vomiting blood disappearance time, and abdominal pain relief time of the treatment group were shorter than those of the control group (P < 0.05). After treatment, the levels of APTT, PT, TT, and FIB in both groups were significantly decreased (P < 0.05), and these coagulation function indicators in the treatment group was lower than those in the control group (P < 0.05). After treatment, the levels of Hb, RBC, and HCT in both groups were significantly increased (P < 0.05), and blood routine indicators in the treatment group was higher than those in the control group (P < 0.05). Conclusion Luohuazizhu Granules combined with Cimetidine Injection is better in treatment of upper gastrointestinal bleeding, with significant advantages in improving coagulation function, enhancing hemostatic effect, and reducing rebleeding rate.

R975

阜阳市自筹类科技计划项目（FK202081085）