目的 探讨舒筋通络颗粒联合普瑞巴林胶囊治疗神经根型颈椎病的临床疗效。方法 选取吉林大学校医院在2022年8月—2024年8月收治的神经根型颈椎病患者共94例，按随机数字表法分为对照组和治疗组，每组47例。对照组服用普瑞巴林胶囊，1粒/次，2次/d。治疗组在对照组基础上口服舒筋通络颗粒，1袋/次，3次/d。两组患者持续治疗1个月。比较两组的治疗效果、颈椎功能、疼痛程度、肌电图指标和血清指标。结果 治疗组的总有效率为93.62%，对照组的总有效率为80.85%，组间差异明显（P＜0.05）。治疗后，两组颈椎功能障碍指数（NDI）评分、上肢和肩颈的数字疼痛强度量表（NRS）评分均显著减小（P＜0.05）；治疗组的NDI评分、上肢和肩颈的NRS评分均小于对照组（P＜0.05）。治疗后，两组尺神经、正中神经的F波传导速度均显著升高（P＜0.05）；治疗组尺神经、正中神经的F波传导速度高于对照组（P＜0.05）。治疗后，两组的血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-18（IL-18）水平均降低（P＜0.05），治疗组的血清TNF-α、IL-1β、IL-18水平更低（P＜0.05）。结论 舒筋通络颗粒联合普瑞巴林胶囊可提高神经根型颈椎病的疗效，改善颈椎功能和减轻疼痛程度，降低炎症反应，改善神经传递速度。

Objective To explore the clinical efficacy of Shujin Tongluo Granules combined with Pregabalin Capsules in treatment of cervical spondylotic radiculopathy. Methods 94 Patients with cervical spondylotic radiculopathy admitted to Jilin University Hospital from August 2022 to August 2024 were divided into control group and treatment group using a random number table method, with 47 patients in each group. The control group patients took Pregabalin Capsules, one capsule each time twice daily. On the basis of the control group, patients in the treatment group were orally administered Shujin Tongluo Granules, 1 bag each time, 3 times daily. The efficacy, cervical spine function, pain level, electromyographic indicators, and serum indicators between two groups were compared. Results The total effective rate of the treatment group was 93.62%, while the total effective rate of the control group was 80.85%, with significant differences between the groups (P< 0.05). NDI scores and NRS in the upper limbs and shoulder neck of both groups were decreased (P < 0.05), and NDI scores and NRS of the upper limbs and shoulder neck in the treatment group was lower than those of the control group (P< 0.05). After treatment, the F-wave conduction velocity of the ulnar nerve and median nerve in both groups were increased (P < 0.05), and these factors in the treatment group was higher than those in the control group (P < 0.05). The levels of TNF-α, IL-1β, and IL-18 in both groups were decreased (P< 0.05), and levels of TNF-α, IL-1β, and IL-18 in the treatment group were lower than those of the control group (P< 0.05). Conclusion The combination of Shujin Tongluo Granules and Pregabalin Capsules can improve the therapeutic effect of cervical spondylotic radiculopathy, further improve cervical function and reduce pain, reduce inflammatory response, improve nerve transmission speed.

R971