流感是人类最常见的呼吸道疾病之一，流感病毒基因突变率高、病毒传播效率高、耐药性迅速出现，造成临床抗病毒治疗的疗效有限。黄芩苷是黄芩中黄酮类化合物，具有多种活性。黄芩苷可通过抑制病毒生长，限制病毒侵入宿主细胞，降低病毒引起的炎症反应，降低病毒引起的肺组织细胞凋亡，纠正病毒引起的肺组织高凝状态发挥抗流感病毒作用。总结了黄芩苷抗流感病毒的药理作用及其作用机制研究进展，为流感的药物治疗提供思路。

Influenza is one of the most common respiratory diseases in humans, and influenza virus has a high mutation rate of influenza virus genes, high virus transmission efficiency, and rapid emergence of drug resistance, resulting in limited efficacy of clinical antiviral treatment. Baicalin is a flavonoid compound in Scutellariae Radix, which has various activities. Baicalin can exert anti-influenza virus effects by inhibiting virus growth, limiting virus invasion into host cells, reducing virus-induced inflammatory responses, lowering virus-induced lung tissue cell apoptosis, and correcting virus-induced hypercoagulable state of lung tissue. This article summarizes the pharmacological effects and mechanisms of baicalin against influenza virus, providing ideas for the drug treatment of influenza.

R285;R286.4

吉林省科技发展计划项目(YDZJ202301ZYTS057)