目的 探讨异维A酸红霉素凝胶联合硫酸羟氯喹片治疗玫瑰痤疮的临床疗效。方法 选取2021年5月—2024年1月天津市宝坻区人民医院收治的100例玫瑰痤疮患者，按随机数字表法将患者分为对照组和治疗组，每组各50例。对照组口服硫酸羟氯喹片，0.2 g/次，2次/d。治疗组在对照组治疗基础上给予异维A酸红霉素凝胶外用，每次清洁患处皮肤并擦干，取适量本品涂抹全部患处，2次/d。两组疗程均为8周。观察两组临床疗效，比较治疗前后病情相关量表[临床医师红斑评估量表（CEA）、整体潮红严重程度量表（GFSS）、研究者整体评价（IGA）评分]评分、玫瑰痤疮生活质量量表（RosaQoL）评分、症状自评量表（SCL-90）评分及毛囊蠕形螨感染情况。结果 治疗后，治疗组总有效率是96.00%，显著高于对照组的84.00%（P＜0.05）。治疗后，两组CEA评分、GFSS评分、IGA评分均较同组治疗前显著降低（P＜0.05）；治疗后，治疗组病情相关量表评分改善优于对照组（P＜0.05）。治疗后，两组患者RosaQoL评分和SCL-90评分均显著降低（P＜0.05）；治疗后，治疗组RosaQoL评分和SCL-90评分低于对照组（P＜0.05）。治疗后，两组2 mm×2 mm和5 mm×5 mm视野范围内的受累毛囊数量和蠕形螨总数均显著减少（P＜0.05）；治疗后，治疗组毛囊蠕形螨感染情况改善优于对照组（P＜0.05）。结论 异维A酸红霉素凝胶联合硫酸羟氯喹片治疗玫瑰痤疮安全性较佳，能有效抑制毛囊蠕形螨感染，减轻红斑、潮红等临床症状，并改善患者生活质量和心理状态，提高病情控制程度，值得临床推广应用。

Objective To investigate the clinical efficacy of Isotretinoin Erythromycin Gel combined with hydroxychloroquine sulfate in treatment of rosacea. Methods A total of 100 patients with rosacea treated in Tianjin Baodi District People’s Hospital from May 2021 to January 2024 were selected and divided into control group and treatment group according to random number table method, with 50 cases in each group. Patie nts in the control group were po administered with Hydroxychloroquine Sulfate Tablets, 0.2 g/time, twice daily. Patients in the treatment group were given Isotretinoin Erythromycin Gel on the basis of the control group, cleaned and dried the affected area each time, applied appropriate amount of this product to all affected areas, twice daily. The treatment course of both groups was 8 weeks. The clinical efficacy of two groups was observed. The disease correlation scales (CEA, GFSS, IGA), RosaQoL, SCL-90 and infection status of demodex folliculorum in two groups before and after treatment were compared. Results After treatment, the total effective rate of treatment group was 96.00%, which was significantly higher than that of control group (84.00%, P < 0.05). After treatment, CEA score, GFSS score, and IGA score in two groups were significantly lower than before treatment (P < 0.05). After treatment, the improvement of disease related scale scores in treatment group was better than that in control group (P < 0.05). After treatment, RosaQoL score and SCL-90 score were significantly decreased in both groups (P < 0.05). After treatment, the scores of RosaQoL and SCL-90 in treatment group were lower than those in control group (P < 0.05). After treatment, the number of affected hair follicles and the total number of demodex in 2 mm×2 mm and 5 mm×5 mm visual fields were significantly decreased in both groups (P < 0.05). After treatment, the infection of demodex follicularis in treatment group was better than that in control group (P < 0.05). Conclusion Isotretinoin Erythromycin Gel combined with hydroxychloroquine sulfate has good safety in treatment of rosacea, and can effectively inhibit demodex folliculorum infection, reduce erythema, flushing and other clinical symptoms, and improve the quality of life and psychological state of patients, improve the degree of disease control, which is worthy of clinical promotion and application.

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