目的 探讨当归龙荟片联合前列地尔治疗肝火上炎型突发性耳聋的临床疗效。方法 选取2021年6月—2023年6月秦皇岛市中医医院收治的突发性耳聋患者120例，采用随机数字法将患者分为对照组（60例）和治疗组（60例）。对照组静脉滴注注射用前列地尔，2 mL加入生理盐水100 mL，1次/d。在对照组的基础上，治疗组患者口服当归龙荟片，4片/次，2次/d。两组患者用药15 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，耳鸣致残量表评分（THI）和欧洲五维生活质量量表评分（EQ-5D-3L）评分，及同型半胱氨酸（Hcy）、降钙素基因相关肽（CGRP）、D-二聚体（D-D）和可溶性血管细胞黏附分子-1（sVCAM-1）水平。结果 治疗后，治疗组总有效率为96.67%，明显高于对照组总有效率（85.00%，P＜0.05）。治疗后，治疗组症状缓解时间比对照组明显缩短（P＜0.05）。治疗后，两组患者THI评分、EQ-5D-3L评分比治疗前明显降低（P＜0.05），且治疗后治疗组THI评分、EQ-5D-3L评分均明显低于对照组（P＜0.05）。治疗后，两组患者Hcy、DD和sVCAM-1水平比治疗前明显降低，而CGRP水平明显升高（P＜0.05），且治疗后治疗组Hcy、DD、sVCAM-1和CGRP水平明显好于对照组（P＜0.05）。结论 当归龙荟片与前列地尔协同治疗，可显著好转突发性耳聋患者的症状及体征，机体炎症反应明显减弱。

Objective To explore the clinical effect of Danggui Longhui Tablets combined with alprostadil in treatment of sudden deafness caused by liver-fire inflammation. Methods Patients (120 cases) with sudden deafness caused by liver-fire inflammation in Qinhuangdao Traditional Chinese Medicine Hospital from June 2021 to June 2023 were divided into control (60 cases) and treatment (60 cases) group by random number method. Patients in the control group were iv administered with Alprostadil for injection, 2 mL added into normal saline 100 mL, once daily. Patients in the treatment group were po administered with Danggui Longhui Tablets, 4 tablets /time, twice daily. Patients in two groups were treated for 15 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the scores of THI and EQ-5D-3L, and the levels of Hcy, D-D, sVCAM-1 and CGRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group was 96.67%, which was significantly higher than that in the control group (85.00%, P < 0.05). After treatment, the symptom relief time in the treatment group was significantly shorter than that in the control group (P < 0.05). After treatment, the THI score and EQ-5D-3L score in both groups were significantly lower than those before treatment (P < 0.05), and the scores in the treatment group were significantly lower than that in the control group (P < 0.05). After treatment, the levels of Hcy, D-D and sVCAM-1 in two groups were significantly lower than those before treatment, while the levels of CGRP were significantly increased (P < 0.05). After treatment, the levels of Hcy, D-D, sVCAM-1, and CGRP in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The coordinated treatment of alprostadil and Danggui Longhui Tablets can significantly improve the symptoms and signs of patients with sudden deafness, and the inflammatory response is significantly weakened.

R987

秦皇岛市科学技术研究与发展计划项目(202005A046)