目的 观察龙金通淋胶囊联合环丙沙星片治疗慢性前列腺炎的临床疗效。方法 选取赤峰市肿瘤医院于2022年6月—2023年12月收治的140例慢性前列腺炎患者作为研究对象，按照随机数字表法将患者分为对照组和治疗组，各为70例。对照组饭前或饭后口服环丙沙星片，1片/次，早晚各1次。治疗组在对照组用药基础上口服龙金通淋胶囊，2～3粒/次，3次/d。两组均治疗1个月。对比两组临床疗效、临床症状、尿动力学指标、血清炎症指标。结果 治疗组的总有效率为90.00%，高于对照组的总有效率74.29%（P＜0.05）。治疗后，两组美国国立卫生研究院慢性前列腺炎症状指数（NIH-CPSI）评分、膀胱残余尿量（PVR）、最大逼尿肌压力、血清肿瘤坏死因子-α（TNF-α）、白细胞介素-8（IL-8）、白细胞介素-17（IL-17）水平均下降，最大尿流率（Q_max）升高（P＜0.05），治疗组的各指标优于对照组（P＜0.05）。结论 龙金通淋胶囊联合环丙沙星片治疗慢性前列腺炎可有效改善患者临床症状和尿动力学指标，降低炎症因子水平。

Objective To observe the clinical study of Longjin Tonglin Capsules combined with Ciprofloxacin Tablets in treatment of chronic prostatitis. Methods 140 Patients with chronic prostatitis in Chifeng Cancer Hospital from June 2022 to December 2023 were divided into control group and treatment group according to the random number table method, with 70 cases in each group. Patients in the control group po administered with Ciprofloxacin Tablets before or after meals, 1 tablets per time, once in the morning and once in the evening. On the basis of the control group, patients in the control group po administered with Longjin Tonglin Capsules, 2 — 3 capsules/time, 3 times daily. Both groups were treated for one month. The clinical efficacy, clinical symptoms, urodynamic indicators, and serum inflammatory indicators between two groups were compared. Results The total effective rate of the treatment group was 90.00%, which was higher than74.29% of the control group (P < 0.05). After treatment, NIH-CPSI score, PVR, maximum detrusor pressure, serum levels of TNF-α, IL-8, and IL-17 in two groups were decreased, while Q_max was increased (P < 0.05). The above indicators in the treatment group were better than those in the control group (P < 0.05). Conclusion Longjin Tonglin Capsules combined with Ciprofloxacin Tablets can effectively improve the clinical symptoms and urodynamic indicators of patients with chronic prostatitis, and reduce the levels of inflammatory factors.

R983

内蒙古自治区卫生健康科技计划项目(202201555)