目的 探讨金鸡胶囊联合多西环素治疗慢性子宫内膜炎的临床疗效。方法 回顾性分析2022年3月—2024年3月在北京航天总医院治疗的慢性子宫内膜炎患者108例，依据用药方式的不同分为对照组和治疗组，每组各54例。对照组患者口服盐酸多西环素肠溶胶囊，0.1 g/次，2次/d。在对照组的基础上，治疗组口服金鸡胶囊，4 粒/次，3次/d。两组患者用药28 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，子宫阻力指数（RI）、血流指数（FI）指标和子宫内膜厚度指标，及炎性因子肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、单核细胞趋化蛋白-1（MCP-1）和白细胞介素-10（IL-10）水平。结果 治疗后，治疗组患者临床总有效率为96.30%，明显高于对照组（79.63%，P＜0.05）。治疗后，治疗组症状好转时间均明显早于对照组（P＜0.05）。治疗后，两组患者子宫RI指标比治疗前明显降低，而FI、子宫内膜厚度指标均明显升高（P＜0.05），且治疗后治疗组这些指标均明显好于对照组（P＜0.05）。治疗后，两组患者TNF-α、IL-1β、MCP-1水平比治疗前明显降低，而IL-10水平明显升高（P＜0.05），且治疗后治疗组炎性因子水平明显好于对照组（P＜0.05）。结论 金鸡胶囊与多西环素协同治疗，能使子宫内膜的炎性症状减轻，并可促进子宫血液微循环有效改善。

Objective To explore the clinical efficacy of Jinji Capsules combined with doxycycline in treatment of chronic endometritis. Methods Patients (108 cases) with chronic endometritis in Beijing Aerospace General Hospital from March 2022 to March 2024 were analyzed retrospectively, and they were divided into control and treatment group based on different treatments, and each group had 54 cases. Patients in the control group were po administered with Doxycycline Hyclate Enteric-Coated Capsules, 0.1 g/time, twice daily. Patients in the treatment group were po administered with Jinji Capsules, 4 grains/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, uterine RI, FI indicators and endometrial thickness indicators, the levels of serological of TNF-α, IL-1β, MCP-1 and IL-10 in two groups before and after treatment were compared. Results After treatment, the clinical efficacy rate in the treatment group was 96.30%, which was significantly higher than that of the control group (79.63%, P < 0.05). After treatment, the symptoms improved time in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, uterine RI indicators in two groups were significantly lower than before treatment, while FI and endometrial thickness indicators were significantly higher (P < 0.05), and these indicators in the treatment group were significantly better than those in the control group (P < 0.05). After treatment, the levels of TNF-α, IL-1β, and MCP-1 in two groups were significantly lower than before treatment, while the level of IL-10 was significantly higher (P < 0.05), and the levels of inflammatory factors in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of Jinji Capsules and doxycycline can alleviate inflammatory symptoms of the endometrium, also promote the effective improvement of uterine blood microcirculation.

R984