目的 探讨伤科接骨片联合骨化三醇治疗女性绝经后骨质疏松性髋部骨折的临床疗效。方法 选取2021年8月—2023年8月聊城市中医医院收治的128例女性绝经后骨质疏松性髋部骨折患者，按随机数字表法将所有患者分为对照组和治疗组，每组各64例。对照组口服骨化三醇软胶囊，1粒/次，2次/d。治疗组在对照组治疗基础上温开水送服伤科接骨片，4片/次，3次/d。两组疗程12周。观察两组临床疗效、临床表现消失时间与骨折临床愈合时间。比较治疗前后两组各时点（即治疗4、8、12周）骨痂骨密度（BMD）值及治疗前后血清肿瘤坏死因子-α（TNF-α）水平。结果 治疗后，治疗组总有效率是95.31%，显著高于对照组的84.38%（P＜0.05）。治疗后，治疗组疼痛、肿胀、压痛消失时间与骨折临床愈合时间均短于对照组（P＜0.05）。治疗组患者治疗4、8、12周的骨痂BMD值显著高于对照组（P＜0.05）。治疗后，两组患者血清TNF-α水平均较治疗前显著降低（P＜0.05）；治疗后治疗组TNF-α水平低于对照组（P＜0.05）。结论 伤科接骨片联合骨化三醇治疗女性绝经后骨质疏松性髋部骨折具有较好疗效，安全性较佳，能有效缓解临床表现，抑制机体炎性损伤，增加骨痂BMD，值得临床推广应用。

Objective To explore the clinical efficacy of Shangke Jiegu Tablets combined with calcitriol in treatment of postmenopausal osteoporotic hip fracture in women. Methods A total of 128 female patients with postmenopausal osteoporotic hip fracture admitted to Liaocheng Hospital of Traditional Chinese Medicine from August 2021 to August 2023 were selected and divided into control group and treatment group according to random number table method, with 64 cases in each group. Patients in the control group were po administered with Calcitriol Soft Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Shangke Jiegu Tablets on the basis of the control group, 4 tablets/time, three times daily. Both groups were treated for 12 weeks. The clinical effect, disappearance time of clinical manifestations and healing time of fracture were observed. The values of callus bone mineral density (BMD) at each time point (i.e. 4, 8, 12 weeks) and serum tumor necrosis factor-α (TNF-α) levels before and after treatment were compared between the two groups. Results After treatment, the total effective rate of the treatment group was 95.31%, which was significantly higher than that of the control group (84.38%, P < 0.05). After treatment, the disappearance time of pain, swelling and tenderness and the clinical healing time of fracture in the treatment group were significantly shorter than those in the control group (P < 0.05). The BMD value of callus in treatment group was significantly higher than that in control group at 4, 8, and 12 weeks after treatment (P < 0.05). After treatment, serum TNF-α levels in both groups were significantly decreased compared with those before treatment (P < 0.05). After treatment, the level of TNF-α in treatment group was lower than that in control group (P <0.05). Conclusion Shangke Jiegu Tablets combined with calcitriol has good efficacy and safety in treatment of postmenopausal osteoporotic hip fracture in women, and can effectively alleviate clinical manifestations, inhibit inflammatory injury, increase BMD of callus, which is worthy of clinical application.

R982

山东省中医药科技项目(M-2023271)