目的 观察小儿咳喘灵泡腾颗粒联合注射用头孢呋辛钠联合治疗儿童支气管肺炎的临床效果。方法 选择2021年12月—2023年7月连云港市第二人民医院收治的儿童支气管肺炎122例，按照随机数字表法将患儿分为对照组（61例）和治疗组（61例）。对照组患儿静脉注射注射用头孢呋辛钠，每天30～100 mg/kg，用无菌注射用水溶解，摇匀后加入静脉输注管内滴注，分3～4次给药。在对照组治疗基础上，治疗组患儿开水冲服小儿咳喘灵泡腾颗粒，2 g/次，3～4次/d。两组患儿均治疗7 d。对比两组临床疗效、临床症状消失时间、血常规指标和血清炎性因子。结果 与对照组总有效率（81.97%）相比，治疗组总有效率（96.72%）更高（P＜0.05）。与对照组相比，治疗组气促、湿啰音、咳嗽、哮鸣音、发热消失时间缩短（P＜0.05）。治疗后，两组患儿嗜酸性粒细胞（EoS）、白细胞（WBC）计数均较治疗前降低（P＜0.05），且治疗组EoS、WBC计数低于对照组（P＜0.05）。治疗后，两组血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、降钙素原（PCT）、C反应蛋白（CRP）水平均较治疗前下降（P＜0.05），治疗组血清IL-6、TNF-α、PCT、CRP水平低于对照组（P＜0.05）。结论 小儿咳喘灵泡腾颗粒、注射用头孢呋辛钠联合治疗儿童支气管肺炎可促进临床症状恢复，改善血常规和炎症因子水平。

Objective To observe the therapeutic effect of Xiaoer Kechuanling Effervescent Granules combine with Cefuroxime Sodium for injection in treatment of children with bronchial pneumonia. Methods Total of 122 children with bronchial pneumonia who were admitted to the Second People's Hospital of Lianyungang from December 2021 to July 2023 were divided into control group (61 cases) and treatment group (61 cases) according to the random table method. Children in the control group were iv administered with Cefuroxime Sodium for injection at a dose of 30 — 100 mg/kg daily, dissolved in sterile injection water, shaken well, and added to the intravenous infusion tube for drip administration divided into 3 — 4 doses. On the basis of the control group, children in the treatment group were po administered with Xiaoer Kechuanling Effervescent Granules in boiling water, 2 g/time, 3 — 4 times daily. Both groups of patients were treated for 7 d. The clinical efficacy, disappearance time of clinical symptoms, blood routine indicators, and serum inflammatory factors were compare between two groups. Results The total clinical effective rate of the treatment group was 96.72%, which was higher than 81.97% of the control group (P < 0.05). The disappearance times of dyspnea, rales, cough, wheezing, and fever in the treatment group was shorter than that in the control group (P < 0.05). After treatment, EoS count and WBC count in both groups were decreased (P < 0.05), and EoS count and WBC count in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-6, TNF-α, PCT, and CRP in both groups were decreased (P < 0.05), and the serum levels of IL-6, TNF-α, PCT, and CRP in the treatment group were lower than those in the control group (P < 0.05). Conclusion The combination of Xiaoer Kechuanling Effervescent Granules and Cefuroxime Sodium for injection can promote the recovery of clinical symptoms, improve blood routine and inflammatory factor levels in children with bronchial pneumonia.

R974;R985

江苏省妇幼保健科研项目(F2022018)