再生障碍性贫血是一种以全血细胞减少、骨髓衰竭为特征的血液免疫功能障碍，其中免疫抑制疗法是最常用的治疗方案。穿龙薯蓣皂苷的结构类似于类固醇激素，具有多种药理作用，可通过增强骨髓增生活性、调节免疫平衡、抑制骨髓细胞凋亡、阻止骨髓细胞成脂化、促进血管新生、降低炎症反应以促进骨髓造血功能恢复，提高有核细胞数量，恢复血象指标水平。总结了穿龙薯蓣皂苷防治再生障碍性贫血的药理作用研究进展，为穿龙薯蓣皂苷的临床应用提供支持。

Aplastic anemia is a blood immune dysfunction characterized by a decrease in whole blood cells and bone marrow failure, and immunosuppressive therapy is the most commonly used treatment method. Dioscorea nipponica saponins has a structure similar to steroid hormones and has multiple pharmacological effects. Dioscorea nipponica saponins can enhance bone marrow proliferation activity, regulate immune balance, inhibit bone marrow cell apoptosis, prevent bone marrow cell lipidation, promote angiogenesis, reduce inflammatory response to promote bone marrow hematopoietic function recovery, increase the number of nuclear cells, and restore blood count indicators. This article summarizes the pharmacological research progress of Dioscorea nipponica saponins in preventing and treating aplastic anemia, providing support for the clinical application of Dioscorea nipponica saponins.

R977

济南市科技局临床医学科技创新计划项目(202004075)