目的 探讨抗骨增生胶囊联合洛索洛芬钠治疗早期膝骨关节炎的临床疗效。方法 选取2021年3月—2023年12月南京市中西医结合医院收治的106例早期膝骨关节炎患者，随机分为对照组（53例）和治疗组（53例）。对照组口服洛索洛芬钠片，60 mg/次，3次/d。治疗组在对照组基础上口服抗骨增生胶囊，5粒/次，3次/d。两组患者均连续治疗4周。观察两组患者临床疗效，比较治疗前后两组牛津膝关节功能评估量表（OKS）评分、视觉模拟评分（VAS）、步态情况、血清炎症指标白细胞介素-6（IL-6）、超敏C反应蛋白（hs-CRP）及不良反应情况。结果 治疗后，与对照组总有效率84.91%比较，治疗组的总有效率（96.23%）明显升高（P＜0.05）。与治疗前比较，治疗后两组OKS评分和VAS评分均明显降低（P＜0.05）；且与对照组比较，治疗后治疗组的OKS评分和VAS评分更低（P＜0.05）。与治疗前比较，治疗后两组的步速、步长均增加（P＜0.05）；与对照组比较，治疗后治疗组的步速、步长增加更明显（P＜0.05）。与治疗前比较，治疗后两组的IL-6、hs-CRP水平均明显降低（P＜0.05）；与对照组比较，治疗后治疗组的IL-6、hs-CRP水平明显更低（P＜0.05）。结论 抗骨增生胶囊联合洛索洛芬钠治疗早期膝骨关节炎疗效较好，能明显减轻疼痛、改善膝关节功能和步态情况，降低炎症反应，不良反应少而轻微。

Objective To explore the therapeutic effect of anti osteoproliferative capsule combined with loxoprofen sodium in treatment of early knee osteoarthritis. Methods Patients (106 cases) with early knee osteoarthritis in Nanjing Integrated Traditional Chinese and Western Medicine Hospital from March 2021 to December 2023 were randomly divided into control group (53 cases) and treatment group (53 cases). Patients in control group were po administered with Loxoprofen Sodium Tablets, 60 mg/time, three times daily. Patients in treatment group were po administered with Kanggu Zengsheng Capsules on basis of control group, 5 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, Oxford Knee Function Assessment Scale (OKS) scores, Visual Analog Scale (VAS), gait status, serum inflammatory levels interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), and adverse reactions in two groups before and after treatment were compared. Results After treatment, compared with the total effective rates (84.91%) in the control group, the total effective rates (96.23%) in the treatment group was higher significant (P < 0.05). Compared with those before treatment, OKS and VAS scores in the treatment group after treatment were lower significant (P < 0.05). Compared with those before treatment, step speed and step length in the treatment group after treatment were higher significant (P < 0.05), and step speed and step length in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels of IL-6 and hs-CRP were significantly reduced in two groups (P < 0.05), and the levels of these indicators in the treatment group decreased more significantly than in the control group (P < 0.05). Conclusion Kanggu Zengsheng Capsules combined with loxoprofen sodium has a good therapeutic effect on in treatment of early knee osteoarthritis, which can significantly reduce pain, improve knee joint function and gait, reduce inflammatory reactions, and have fewer and milder adverse reactions.

R977

江苏省卫生健康委科研课题(ZD2020036)