目的 分析金花消痤丸联合异维A酸治疗重度痤疮的临床疗效。方法 选取2021年1月—2023年8月白银市中心医院收治的92例重度痤疮患者，按随机数字表法分为对照组和治疗组，每组各46例。对照组口服异维A酸软胶囊，10 mg/次，2次/d。治疗组在此基础上口服金花消痤丸，4 g/次，3次/d。两组疗程8周。观察两组的临床疗效，比较治疗前后痤疮综合评分系统（GAGS）评分、简式抑郁-焦虑-压力量表（DASS-21）评分、36项健康调查简表（SF-36）评分和面部皮损处皮肤生理指标的变化。结果 治疗后，治疗组总有效率是95.65%，对照组是82.61%，两组比较差异显著（P＜0.05）。治疗后，两组GAGS中各区域分值及其总评分均显著降低（P＜0.05）；治疗后，治疗组GAGS评分低于对照组（P＜0.05）。治疗后，两组DASS-21评分均显著降低，SF-36评分则均显著增加（P＜0.05）；DASS-21、SF-36评分以治疗组患者改善更显著（P＜0.05）。治疗后，两组角质层含水量均显著增加，皮脂含量、经皮水分丢失（TEWL）值、pH值均显著降低（P＜0.05）；治疗后，治疗组皮肤生理指标改善更显著（P＜0.05）。结论 金花消痤丸联合异维A酸治疗重度痤疮的效果确切，能有效减轻皮损表现，抑制皮脂分泌，促进皮肤屏障功能恢复，降低对患者情绪状态和生活质量的影响。

Objective To analyze the clinical effect of Jinhua Xiaocuo Pills combined with isotretinoin in treatment of severe acne. Methods Ninety-two patients with severe acne treated in Baiyin Central Hospital from January 2021 to August 2023 were selected and divided into control group and treatment group according to random number table method, with 46 cases in each group. Patients in the control group were po administered with Isotretinoin Soft Capsules, 10 mg/time, twice daily. Patients in the treatment group were po administered with Jinhua Xiaocuo Pills on the basis of the control group, 4 g/time, three times daily. Both groups were treated for 8 weeks. The clinical effects of the two groups were observed, and the changes of GAGS score, DASS-21 score, 36-item health survey Summary Form (SF-36) score and skin physiological indexes of facial lesions were compared before and after treatment. Results After treatment, the total effective rate was 95.65% in the treatment group and 82.61% in the control group, with significant difference between the two groups (P < 0.05). After treatment, GAGS scores and total scores in both groups were significantly decreased (P < 0.05). After treatment, GAGS score in the treatment group was lower than that in the control group (P < 0.05). After treatment, DASS-21 scores were significantly decreased, while SF-36 scores were significantly increased in both groups (P < 0.05). The improvement of DASS-21 and SF-36 scores in the treatment group was more significant (P < 0.05). After treatment, water content of stratum corneum was significantly increased, sebum content, transcutaneous water loss (TEWL) value and pH value were significantly decreased in both groups (P < 0.05). After treatment, the improvement of skin physiological indexes in the treatment group was more significant (P < 0.05). Conclusion Jinhua Xiaocuo Pills combined with isotretin has definite effect in treatment of severe acne, and can effectively reduce the manifestations of skin lesions, inhibit sebum secretion, promote the recovery of skin barrier function, and reduce the impact on the emotional state and quality of life of patients.

R986