目的 探讨老年慢性功能性便秘患者使用麻仁丸、双歧杆菌三联活菌胶囊联合治疗的疗效。方法 收集2021年3月—2023年3月无锡市中医医院73例慢性功能性便秘患者资料，根据用药方案不同将患者分为对照组（36例）和治疗组（37例）。对照组口服双歧杆菌三联活菌胶囊，2粒/次，2次/d。在此基础上，治疗组口服麻仁丸，1丸/次，2次/d。两组持续治疗4周。比较两组患者临床疗效、症状缓解时间、生活质量、胃肠道功能以及复发情况。结果 治疗组的总有效率为94.59%，高于对照组总有效率69.44%（P＜0.05）。治疗组患者腹胀缓解时间、肛门坠胀感缓解时间、排便困难缓解时间短于对照组（P＜0.05）。治疗后，两组国际便秘生活质量量表（PAC-QOL）评分均降低（P＜0.05），且治疗组患者PAC-QOL评分更低（P＜0.05）。治疗后，两组血清胃泌素（GAS）、促胃动素（MTL）、P物质（SP）水平均升高（P＜0.05），且治疗组血清GAS、MTL、SP水平更高（P＜0.05）。随访3个月时，治疗组复发率低于对照组，差异有统计学意义（P＜0.05）。结论 老年慢性功能性便秘患者使用麻仁丸、双歧杆菌三联活菌联合治疗可加速症状缓解，提高患者胃肠道功能和生活质量，降低复发率，疗效显著。

Objective To investigate the efficacy of Maren Pills combined with Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules in treatment of elderly chronic functional constipation. Methods The data of 73 patients with elderly chronic functional constipation in Wuxi Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were collected, and the patients were divided into control group (36 cases) and treatment group (37 cases) according to different medication regimens. Patients in the control group took Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules orally, 2 capsules/time, twice daily. Patients in the treatment group were given Maren Pills orally, 1 pill/time, 2 times daily on the basis of the control group. Patients in both groups were treated for 4 weeks. The efficacy, symptom relief time, gastrointestinal function, quality of life, as well as recurrence at 3-month follow-up were compared between the two groups of patients. Results The total effective rate of the treatment group was 94.59%, which was higher than 69.44% of the control group (P < 0.05). The relief time of abdominal distension, anal distension, and defecation difficulty in the treatment group was shorter than those in the control group (P < 0.05). After treatment, PAC-QOL scores of both groups were significantly decreased (P < 0.05), and PAC-QOL scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, the serum levels of GAS, MTL, and SP in both groups were significantly increased (P < 0.05). The serum levels of GAS, MTL, and SP in the treatment group were higher than those in the control group (P < 0.05). At the 3-month follow-up, the recurrence rate of the treatment group was lower than that of the control group, with a statistical significant difference (P < 0.05). Conclusion The combination of Maren Pills and Live Combined Bifidobacterium, Lactobacillus and Enterococcus Capsules in treatment of elderly chronic functional constipation can accelerate the relief of symptoms, improve the gastrointestinal function and quality of life of patients, reduce the recurrence rate, and have a significant effect.

R975

江苏省卫生健康委科研项目(M2022021);无锡市“双百”卫生健康中青年拔尖人才项目(BJ2023067)