目的 观察银丹心泰滴丸联合尼可地尔治疗微血管性心绞痛的临床疗效。方法 选取2022年4月—2024年4月宜昌市第二人民医院收治的126例微血管性心绞痛者，依据用药情况随机分为对照组（63例）和治疗组（63例）。对照组患者口服尼可地尔片，1片/次，3次/d。在对照组的基础上，治疗组口服银丹心泰滴丸，10丸/次，3次/d。两组患者用药28 d。观察两组患者临床疗效，比较治疗前后两组患者症状缓解时间，心功能的舒张末期血流速度（EDV）、收缩期最大流速（PSV）、阻力指数（RI）、搏动指数（PI）指标、白细胞介素-6（IL-6）、内皮素-1（ET-1）、内皮特异分子-1（ESM-1）和超敏C反应蛋白（hs-CRP）水平。结果 治疗后，治疗组总有效率（98.41%）明显高于对照组（84.13%，P＜0.05)。治疗后，两组6 min步行试验（6MWT）、西雅图心绞痛评分（SAQ）比治疗前明显升高（P＜0.05），且治疗组6MWT、SAQ评分均明显高于对照组（P＜0.05）。治疗后，两组患者EDV、PSV、PI比治疗前明显升高，而RI、ET-1、IL-6、ESM-1、hs-CRP比治疗前明显降低（P＜0.05），且治疗组血流动力学和炎性因子指标水平明显好于对照组（P＜0.05）。结论 银丹心泰滴丸与尼可地尔协同治疗能较好地改善微血管性心绞痛患者症状，调节机体血流变学状态，促进心功能增强，减弱炎症反应。

Objective To explore the clinical efficacy of Yindan Xintai Dropping Pills combined with nicorandil in treatment of microvascular angina. Methods Patients (126 cases) with microvascular angina in the Second People’s Hospital of Yichang from April 2022 to April 2024 were divided into control (63 cases) and treatment (63 cases) group according to drug use. Patients in the control group were po administered with Nicorandil Tablets, 1 tablet/time, three times daily. Patients in the treatment group were po administered with Yindan Xintai Dropping Pills, 10 pills/time, three times daily. Patients in two groups were treated for 28 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, and the levels of EDV, PSV, RI, PI, ET-1, IL-6, ESM-1 and hs-CRP in two groups before and after treatment were compared. Results After treatment, the clinical effective rate in the treatment group (98.41%) was significantly higher than that in the control group (84.13%, P < 0.05). After treatment, the 6MWT and SAQ in two groups were significantly higher than those before treatment (P < 0.05), and which in the treatment group were significantly higher than those in the control group (P < 0.05). After treatment, EDV, PSV and PI in two groups were significantly higher than before treatment, but RI, ET-1, IL-6, ESM-1 and hs-CRP were significantly lower than before treatment (P < 0.05), and the levels of hemodynamics and inflammatory factor indicators in the treatment group were significantly better than those in the control group (P < 0.05). Conclusion The synergistic treatment of Yindan Xintai Dropping Pills and nicorandil can improve the symptoms of patients with microvascular angina, regulate hemorheological status, promote the enhancement of cardiac function, and weaken inflammatory reactions.

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