目的 探讨稳心颗粒联合注射用磷酸肌酸钠治疗病毒性心肌炎的临床疗效。方法 选择北京市仁和医院在2022年6月—2024年3月收治的79例病毒性心肌炎患者，按随机数字表法将患者分为对照组（40例）和治疗组（39例）。对照组静脉滴注注射用磷酸肌酸钠，1瓶加入150 mL生理盐水中在30～45 min内滴注完，1次/d；治疗组在对照组基础上口服稳心颗粒，1袋/次，3次/d。两组连续治疗4周。比较两组患者的总有效率、心功能指标和血清指标。结果 治疗组的总有效率为94.87%，对照组的总有效率为80.00%，两组组间比较差异显著（P＜0.05）。治疗后，两组的左心室（LV）-Tei、右心室（RV）-Tei均显著降低（P＜0.05）；治疗组的LV-Tei、RV-Tei比对照组小（P＜0.05）。治疗后，两组患者的血清肌酸激酶同工酶（CK-MB）、高迁移率族蛋白B1（HMGB1）、白细胞介素-37（IL-37）水平均显著降低，血清adropin水平显著升高（P＜0.05）；治疗组的血清CK-MB、HMGB1、IL-37水平均比对照组小，血清adropin水平比对照组大（P＜0.05）。结论 稳心颗粒联合注射用磷酸肌酸钠可提高病毒性心肌炎的临床疗效，改善心功能，减轻心肌炎症损伤。

Objective To explore the efficacy of Wenxin Granules combined with Creatine Phosphate Sodium for injection in treatment of viral myocarditis. Methods 79 Patients with viral myocarditis admitted to Beijing Renhe Hospital from June 2022 to March 2024 were divided into a control group (40 cases) and a treatment group (39 cases) according to random number table method . Patients in the control group received intravenous infusion of Creatine Phosphate Sodium for injection, adding 1 bottle to 150 mL physiological saline and dripping it within 30 — 45 min, once daily. Patients of the treatment group were po administered with Wenxin Granules on the basis of the control group, 1 bag/time, 3 times daily. Patients of two groups were treated continuously for 4 weeks. The total effective rate, cardiac function indicators, and serum indicators of two groups of patients were compared. Results The total effective rate of the treatment group (94.87%) was higher than 80.00% of the control group, and there was a significant difference between the groups (P < 0.05). LV-Tei and RV-Tei of both groups after treatment were smaller than those before treatment (P < 0.05). LV-Tei and RV-Tei of the treatment group after treatment were smaller than those of the control group (P < 0.05). After treatment, the serum levels of CK-MB, HMGB1, and IL-37 in both groups were lower than those before treatment, while the serum level of adropin in both groups was higher than those after treatment (P < 0.05). The serum levels of CK-MB, HMGB1, and IL-37 in the treatment group were all lower than those in the control group, while the serum level of adropin in the treatment group was higher than that in the control group (P < 0.05). Conclusion The combination of Wenxin Granules and Creatine Phosphate Sodium for injection can improve the efficacy of viral myocarditis, improve heart function, and reduce myocarditis damage.

R972

北京市科技计划课题(Z171100001017133)