[关键词]
[摘要]
目的 探讨乌灵胶囊联合盐酸米那普仑片治疗焦虑症的临床疗效。方法 选择2021年4月—2024年3月石家庄市第八医院就诊的111例焦虑症患者,按随机数字表法将患者分为对照组(56例)和治疗组(55例)。对照组口服盐酸米那普仑片,初始剂量1片/次,持续1周后调整为维持剂量2片/次,2次/d;治疗组患者在对照组基础上口服乌灵胶囊,3粒/次,3次/d。两组患者连续治疗2个月。比较两组患者的临床疗效、主观焦虑程度和血清指标水平。结果 治疗组的总有效率为94.55%,高于对照组的总有效率82.14%,组间比较差异显著(P<0.05)。治疗后,两组的焦虑自评量表(SAS)、汉密尔顿焦虑量表(HAMA)评分均显著降低(P<0.05),且治疗组的SAS、HAMA评分比对照组更低(P<0.05)。治疗后,两组的血清神经肽Y(NPY)水平显著升高,血清多巴胺(DA)、5-羟色胺(5-HT)水平显著降低(P<0.05);治疗组的血清NPY水平比对照组高,血清DA、5-HT水平比对照组低(P<0.05)。结论 乌灵胶囊联合盐酸米那普仑片可提高焦虑症的临床疗效,减轻焦虑程度,可能与调节神经递质分泌有关。
[Key word]
[Abstract]
Objective To explore the clinical efficacy of Wuling Capsules combined with Milnacipran Hydrochloride Tablets in treatment of anxiety disorders. Methods 111 Patients with anxiety disorder in Shijiazhuang Eighth Hospital from April 2021 to March 2024 were divided into control group (56 cases) and treatment group (55 cases) according to random number table method. Patients of the control group were po administered with Milnacipran Hydrochloride Tablets, the initial dose was 1 tablet/time, and was adjusted to the maintenance dose after 1 week, 2 tablets/time, 2 times daily. Patients of the treatment group were given Wuling Capsules on the basis of the control group, 3 capsules/time, 3 times daily. Patients in two groups were treated for 2 months. The clinical efficacy, subjective anxiety degree and serum index level of two groups were compared. Results The total effective rate of the treatment group (94.55%) was higher than 82.14% of the control group, and the difference between the groups was significant (P < 0.05). After treatment, SAS scores and HAMA scores of both groups were significantly decreased (P < 0.05), and SAS scores and HAMA scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, NPY was significantly increased, but DA and 5-HT were significantly decreased in both groups (P < 0.05). NPY in the treatment group was higher than that in the control group, but DA and 5-HT in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wuling Capsules combined with Milnacipran Hydrochloride Tablets can improve the therapeutic effect of anxiety disorders, reduce anxiety levels, and may be related to the regulation of neurotransmitter secretion.
[中图分类号]
R971
[基金项目]
河北省医学科学研究项目(20230411)