皮肤病可引起不同程度的瘙痒、疼痛，影响美观，还严重影响患者的生活质量。苦参碱是苦参中提取的生物碱，具有多种药理作用，可通过调节免疫反应、减轻炎症损伤、增强细胞自噬、促进细胞凋亡、镇痛止痒、抗皮肤纤维化等多途径、多靶点对多种皮肤病发挥治疗作用。总结了苦参碱治疗皮肤疾病的药理作用研究进展，为苦参碱的临床应用提供参考。

Skin diseases can cause varying degrees of itching, pain, affect aesthetics, and seriously affect the quality of life of patients. Matrine is an alkaloid from Sophorae Flavescentis Radix, which has various pharmacological effects. Matrine can treat various skin diseases through multiple pathways and targets, such as regulating immune response, reducing inflammatory damage, enhancing cell autophagy, promoting cell apoptosis, relieving pain and itching, and resisting skin fibrosis. This article summarizes the pharmacological research progress of matrine in treatment of skin diseases, providing reference for the clinical application of matrine.

R986

国家自然科学基金资助项目(81973846)