目的 探讨金喉健喷雾剂联合甘桔冰梅片治疗慢性咽炎的临床疗效。方法 选取2022年1月—2023年12月在青岛市城阳区人民医院就诊的98例慢性咽炎患者，按随机数字表法将所有患者分为对照组和治疗组，每组49例。对照组口服甘桔冰梅片，2片/次，3次/d。治疗组在对照组基础上使用金喉健喷雾剂，2喷/次，3次/d。两组患者持续治疗30 d。比较两组患者的临床疗效、症状缓解时间和血清指标。结果 治疗后，治疗组总有效率为95.92%，对照组总有效率为81.63%，组间比较差异明显（P＜0.05）。治疗后，治疗组患者咽喉疼痛、干痒、黏膜充血、异物感缓解时间均短于对照组，差异有统计学意义（P＜0.05）。治疗后，两组血清白细胞介素-2（IL-2）水平升高，血清白细胞介素-6（IL-6）、分泌型免疫球蛋白A（sIgA）水平降低（P＜0.05）；治疗组血清IL-2水平高于对照组，血清IL-6、sIgA水平低于对照组（P＜0.05）。结论 金喉健喷雾剂联合甘桔冰梅片可提高慢性咽炎的疗效，促进症状改善，降低炎症损伤。

Objective To investigate the clinical effect of Jinhoujian Spray combined with Ganju Bingmei Tablets in treatment of chronic pharyngitis. Methods 98 Patients with chronic pharyngitis treated in Qingdao Chengyang District People’s Hospital from January 2022 to December 2023 were selected and divided into control group and treatment group according to random number table method, with 49 cases in each group. Patients in control group were given Ganju Bingmei Tablets, 2 tablets/time, 3 times daily. On the basis of the control group, patients in the treatment group was treated with Jinhoujian Spray, 2 sprays/time, 3 times daily. The therapeutic effect, the duration of symptom remission, and serum levels of factors were compared. Results After treatment, the total effective rate was 81.63% in the control group, 95.92% in the treatment group, and the difference between groups was significant (P < 0.05). After treatment, the relief time of sore throat, dry itching, mucosal congestion, and foreign body sensation in the treatment group was shorter than that in the control group (P < 0.05). After treatment, the serum levels of IL-2 in two groups was higher than that before treatment, but the serum levels of IL-6 and sIgA in two groups were lower than those before treatment (P < 0.05). After treatment, the serum levels of IL-2 in the treatment group was higher than that of control group, but the serum levels of IL-6 and sIgA in the treatment group were lower than those of control group (P < 0.05). Conclusion Jinhoujian Spray combined with Ganju Bingmei Tablets can improve the curative effect of chronic pharyngitis, promote the improvement of symptoms, and reduce inflammation damage.

R987

青岛市医药卫生科研计划项目(2021-WJZD271)