目的 探讨痰热清注射液联合注射用替加环素治疗医院获得性肺炎的临床疗效。方法 选取2022年3月—2023年11月在天津中医药大学第二附属医院就诊的85例医院获得性肺炎患者，按随机数字表法将患者分为对照组（42例）和治疗组（43例）。对照组静脉滴注注射用替加环素，首次静滴剂量100 mg，1次/d，之后每12小时1次，每次50 mg，每次持续30～60 min。治疗组在对照组基础上静滴痰热清注射液，20 mL/次，1次/d。两组持续治疗10 d。比较两组临床疗效、症状消失时间、病情程度和血清指标。结果 治疗后，治疗组的总有效率为95.35%，对照组的总有效率为80.95%，组间比较差异有统计学意义（P＜0.05）。治疗后，治疗组高热、咳嗽、肺啰音、肺部阴影消失时间均短于对照组（P＜0.05）。治疗后，两组临床肺部感染评分（CPIS）均明显下降（P＜0.05），治疗组CPIS评分明显低于对照组（P＜0.05）。治疗后，两组患者的血清髓样细胞触发受体-1（TREM-1）、载脂蛋白E（ApoE）、降钙素原（PCT）水平均低于治疗前（P＜0.05）；治疗组的血清TREM-1、ApoE、PCT水平低于对照组（P＜0.05）。结论 痰热清注射液联合注射用替加环素可提高医院获得性肺炎的临床疗效，有效控制病情，改善临床症状，降低炎症反应。

Objective To investigate the curative effect of Tanreqing Injection combined with Tigacycline for injection in treatment of hospital-acquired pneumonia. Methods A total of 85 patients with hospital-acquired pneumonia treated in the Second Affiliated Hospital of Tianjin University of Chinese Medicine from March 2022 to November 2023 were selected and divided into control group (42 cases) and treatment group (43 cases) according to random number table method. Patients in the control group were given intravenous Tigecycline for injection, the first dose of 100 mg, once daily, and then once every 12 h, 50 mg/time, for 30 to 60 min. Patients in the treatment group were given Tanreqing Injection on the basis of control group, 20 mL/time, once daily. Patients of two groups were treated for 10 d. The clinical efficacy, symptom disappearance time, disease degree, and serum indexes were compared between two groups. Results The total effective rate of patients in the treatment group was 95.35%, and that in the control group was 80.95%, and the difference between groups was significant (P < 0.05). The disappearance time of high fever, cough, lung rales, and lung shadows in the treatment group was shorter than that in the control group (P < 0.05). CPIS score in both groups were decreased significantly, and CPIS score of the treatment group was significantly lower than that in the control group (P < 0.05). After treatment, the serum levels of TREM-1, ApoE, and PCT in both groups were lower than that before treatment (P < 0.05), and the serum levels of TREM-1, ApoE, and PCT in the treatment group were lower than those in the control group (P < 0.05). Conclusion Tanreqing Injection combined with Tigacycline for injection can improve the curative effect of hospital-acquired pneumonia, effectively control the disease, improve the efficiency of symptom improvement, and reduce the inflammatory reaction.

R974

天津市教委科研究计划项目(自然科学)(82104800)