目的 探讨腰痹通胶囊联合地奥司明片治疗腰椎管狭窄症的临床疗效。方法 选取2021年6月—2024年5月在张家口市第一医院就诊的94例腰椎管狭窄症患者，按随机数字表法将患者分为对照组和治疗组，每组47例。对照组午餐、晚餐后口服地奥司明片，1片/次。治疗组在对照组基础上口服腰痹通胶囊，3粒/次，3次/d。两组患者持续治疗4周。比较两组患者的临床疗效、腰椎功能和血清指标。结果 治疗后，治疗组的总有效率为95.74%，对照组的总有效率为82.98%，组间比较差异显著（P＜0.05）。治疗后，两组Oswestry功能障碍指数（ODI）评分显著减小（P＜0.05），且治疗组ODI评分较对照组更小（P＜0.05）。治疗后，两组的血清白细胞介素-1α（IL-1α）、基质金属蛋白酶-3（MMP-3）、白细胞介素-18（IL-18）水平均降低（P＜0.05）；治疗组的血清IL-1α、MMP-3、IL-18水平均低于对照组（P＜0.05）。结论 腰痹通胶囊联合地奥司明片可提高腰椎管狭窄症的疗效，改善患者腰椎功能，降低炎症反应。

Objective To investigate the clinical study of Yaobitong Capsules combined with Diosming Tablets in treatment of lumbar spinal stenosis. Methods 94 Patients with lumbar spinal stenosis who visited Zhangjiakou First Hospital from June 2021 to May 2024 were selected and divided into control group and treatment group using a random number table method, with 47 patients in each group. The patients in the control group were po administered with Diosmin Tablets after lunch and dinner, 1 tablets/time. The patients in the treatment group were po administered with Yaobitong Capsules on the basis of the control group, 3 grains/time, 3 times daily. Two groups of patients were treated continuously for 4 weeks. The clinical efficacy, lumbar function, and serum indexes of the two groups were compared. Results After treatment, the total effective rate was 95.74% in the treatment group, and 82.98% in the control group, and the difference was significant between two groups (P < 0.05). After treatment, ODI scores of the two groups was significantly decreased (P < 0.05), and ODI score of the treatment group was lower than that of the control group (P < 0.05). After treatment, the serum levels of IL-1α, MMP-3, and IL-18 in two groups were decreased (P < 0.05), and the serum levels of IL-1α, MMP-3, and IL-18 in the treatment group were lower than those in the control group (P < 0.05). Conclusion Yaobitong Capsules combined withDiosming Tablets can improve the curative effect of lumbar spinal stenosis, improve the function of lumbar spine and reduce the inflammatory response.

R971

张家口市重点研发计划项目(2121059D)