微管蛋白抑制剂特异性作用于微管蛋白、干扰细胞有丝分裂、造成细胞周期停滞，从而诱导细胞凋亡。微管蛋白抑制剂按其结合部位可分为作用于秋水仙碱位点、长春花碱位点和紫杉醇位点的抗寄生虫微管蛋白抑制剂。综述了微管蛋白抑制剂抗寄生虫病的研究进展及其作用机制，旨在对抗寄生虫药物的研究提供参考。

Microtubule protein inhibitors specifically act on microtubules, interfere with cell mitosis, cause cell cycle arrest, and induce cell apoptosis. Microtubule protein inhibitors can be classified as antiparasitic microtubule protein inhibitors that act on colchicine sites, vinblastine sites, and paclitaxel sites according to their binding sites. This article reviews the research progress and its mechanism of microtubule protein inhibitors against parasitic diseases, aiming to provide reference for the study of antiparasitic drugs.

R962

青海省基础研究计划项目（2023-0302-ZJC-0125）；青海省“昆仑英才·高端创新创业人才”项目