多药耐药构成了一种独特而关键的耐药谱，严重影响肿瘤的治疗效果。中药联合化疗药物不仅可以降低化疗引起的不良反应，还可以增强化疗效果，逆转多药耐药。紫草素是从紫草根中提取的萘醌类化合物，具有广泛的药理作用。紫草素联合顺铂、吉非替尼、奥沙利铂、阿霉素、紫杉醇、他莫昔芬等化疗药物的疗效更显著，其可通过多种分子机制来降低肿瘤细胞对化疗药物的敏感性。阐述紫草素与多种化疗药物联合使用逆转肿瘤耐药性的研究进展，以期为临床克服肿瘤治疗耐药性提供参考。

Multidrug resistance constitutes a unique and critical spectrum of drug resistance, which seriously affects the therapeutic efficacy of tumors. The combination of traditional Chinese medicine and chemotherapy drugs can not only reduce the adverse reactions caused by chemotherapy, but also enhance the efficacy of chemotherapy and reverse multidrug resistance. Shikonin is a naphthoquinone compound extracted from Arnebiae Radix, which has a wide range of pharmacological effects. The combination of shikonin and chemotherapy drugs such as cisplatin, gefitinib, oxaliplatin, doxorubicin, paclitaxel, and tamoxifen has a more significant therapeutic effect, and it can reduce the sensitivity of tumor cells to chemotherapy drugs through various molecular mechanisms. This article summarizes the research progress on shikonin in combination with multiple chemotherapy drugs to reverse tumor resistance, in order to provide reference for overcoming tumor treatment resistance in clinical practice.

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国家自然科学基金资助项目（81402344）；陕西省自然科学基础研究计划项目（2023-JC-YB-745）