目的 建立西维来司他钠的药物利用评价（DUE）标准，应用加权TOPSIS法评价其临床应用的合理性，为临床合理使用西维来司他钠提供参考。方法 以西维来司他钠药品说明书、相关共识等为参考，制定西维来司他钠合理用药评价标准。根据制定的标准，利用PASS系统抽取2023年1月—12月六安市人民医院使用西维来司他钠的128份住院患者的病例信息，并采用加权TOPSIS法对抽取的病历进行分析，评价用药合理性。结果 西维来司他钠完全符合评价标准的病例有63例（49.2%），用药不适宜主要表现在适应证43例（33.6%）、辅助检查及实验室检查27例（21.1%）、用法用量18例（14.1%）、用药疗程18例（14.1%）、不良反应10例（12.8%）。通过加权TOPSIS法，判定为合理用药83例（64.8%），基本合理用药5例（3.9%），不合理用药40例（31.3%）。结论 通过建立西维来司他钠临床应用的合理性评价标准，发现西维来司他钠临床使用合理率占比较高，但仍存在使用不合理现象，通过前置审方系统完善西维来司他钠用药规则，促进药物合理、规范使用。

Objective To establish the criteria for drug utilization evaluation (DUE) of sivelestat sodium, and apply the weighted TOPSIS method to evaluate the rationality of its clinical application, so as to provide reference for rational clinical use of sivelestat sodium. Methods The evaluation criteria for rational drug use of sivelestat sodium were established with reference to the drug instructions and relevant consensus of sivelestat sodium. According to the established criteria, the data of 128 inpatients using cilvelestat sodium in Lu’an People’s Hospital from January to December 2023 were extracted by the PASS system, and the extracted medical records were analyzed by weighted TOPSIS method to evaluate the rationality of drug use. Results There were 63 cases (49.2%) in which sivelestat sodium fully met the evaluation criteria. The inappropriateness of medication was mainly manifested in: There were 43 cases (33.6%) of indications, 27 cases (21.1%) of auxiliary examination and laboratory examination, 18 cases (14.1%) of usage and dosage, 18 cases (14.1%) of treatment course, and 10 cases (12.8%) of adverse reactions. By weighted TOPSIS method, 83 cases (64.8%) were judged to be rational drug use, 5 cases (3.9%) were basically rational drug use, and 40 cases (31.3%) were irrational drug use. Conclusion Through the establishment of rational evaluation criteria for clinical application of sivelestat sodium, it can be seen from the results that the rational rate of clinical use of sivelestat sodium is relatively high, but there are still irrational use. The pre-review prescription system is used to improve the medication rules of sivelestat sodium, and promote the rational and standardized use of drugs.

R974

安徽省教育厅高校科学研究项目（KJ2021A0342）