目的 观察坤泰胶囊联合氯喹那多–普罗雌烯阴道片治疗老年性阴道炎的临床疗效。方法 选取2020年6月—2022年6月无锡市妇幼保健院收治的101例老年性阴道炎患者作为研究对象，根据治疗方案不同分为对照组（50例）和治疗组（51例）。对照组使用氯喹那多–普罗雌烯阴道片，睡前清洁外阴，佩戴手套，阴道深处塞入氯喹那多–普罗雌烯阴道片，1片/次，1次/d。治疗组在对照组基础上口服坤泰胶囊，4粒/次，3次/d。两组均治疗18 d。比较两组临床疗效、复发率、阴道清洁程度、阴道健康水平、性激素水平。结果 治疗后，治疗组的总有效率较对照组更高（88.24% vs 70.00%），治疗组的复发率低于对照组（17.65% vs 36.00%，P＜0.05）。治疗后，两组患者阴道清洁度正常率均显著升高（P＜0.05），治疗组阴道清洁度正常率高于对照组（P＜0.05）。治疗后，两组阴道健康评分均上升（P＜0.05），且治疗组阴道健康评分高于对照组（P＜0.05）。治疗后，两组血清卵泡刺激素（FSH）、黄体生成素（LH）均下降，血清雌二醇（E₂）均上升（P＜0.05），且治疗组血清FSH、LH低于对照组，血清E₂较高于对照组（P＜0.05）。结论 坤泰胶囊联合氯喹那多–普罗雌烯阴道片可有效治疗老年性阴道炎，提高阴道健康和清洁程度，改善患者性激素水平。

Objective To observe the clinical efficacy of Kuntai Capsules combined with Chlorquinaldol Promestriene Vaginal Tablets in treatment of senile vaginitis. Methods A total of 101 women with senile vaginitis admitted to Wuxi Maternal and Child Health Hospital from June 2020 to June 2022 were selected as the study objects. According to different treatment plans, women were divided into the control group (50 cases) and treatment group (51 cases). Women in the control group were treated with Chlorquinaldol Promestriene Vaginal Tablets, the vulva was cleaned with water before going to bed every day, and the Chlorquinaldol Promestriene Vaginal Tablets were inserted into the depths of the vagina, 1 tablet/time, once daily. Women in the treatment group were po administered with Kuntai Capsules on the basis of the control group, 4 capsules/time, 3 times daily. Patients were treated for 18 d. The clinical efficacy, recurrence rate, vaginal cleanliness, vaginal health level, and sex hormone level were compared between two groups. Results Compared with control group, the total clinical efficacy rate of the treatment group was significantly higher than that of the control group (88.24% vs 70.00%), and the recurrence rate (36.00%) of the treatment group was significantly lower than 17.65% of the control group (P < 0.05). After treatment, the normal rate of vaginal cleanliness in two groups was significantly increased (P < 0.05). Compared with the control group, the normal rate of vaginal cleanliness in the treatment group was significantly higher than these after treatment, with statistical significant differences (P < 0.05). Compared with the control group, the serum levels of FSH and LH in two group were decreased, while the serum levels of E₂ were increased (P < 0.05), and the serum levels of FSH and LH in treatment group were lower than those in the control group, while the serum levels of E₂ in the treatment group was higher than those in the control group (P < 0.05). Conclusion Kuntai Capsules combined with Chlorquinaldol Promestriene Vaginal Tablets has a good therapeutic effect on senile vaginitis, can improve the health and cleanliness of the vagina, and effectively improve the level of sex hormones.

R984

江苏省妇幼健康科研项目（F202107）