目的 探讨参苓白术颗粒联合复方胰酶散治疗小儿功能性消化不良的临床疗效。方法 选取2022年8月—2023年12月在榆林市第一医院接受治疗的功能性消化不良患儿96例，依据随机数字表法分为对照组和治疗组，每组各48例。对照组口服复方胰酶散，2袋/次，3次/d。治疗组在对照组治疗基础上口服参苓白术颗粒，3 g/次，3次/d。两组均连续治疗2周。观察两组的临床疗效和中医症状消失时间，比较两组治疗前后胃排空率、胃动素、降钙素基因相关肽（CGRP）的变化情况。结果 治疗后，治疗组总有效率是95.83%，显著高于对照组的83.33%（P＜0.05）。治疗后，与对照组比较，治疗组脘腹痞满、食少纳呆、胃脘隐痛消失时间更短（P＜0.05）。治疗后，两组餐后30、60 min的胃排空率明显升高（P＜0.05）；治疗后，治疗组餐后30、60 min的胃排空率高于对照组（P＜0.05）。治疗后，两组血清胃动素水平明显升高，血清CGRP水平明显降低（P＜0.05）；与对照组治疗后比较，治疗组血清胃动素水平更高、血清CGRP水平更低（P＜0.05）。结论 参苓白术颗粒联合复方胰酶散治疗小儿功能性消化不良可获得较佳的治疗效果，并能有效改善胃排空延迟及血清胃动素、CGRP水平，且安全性较高。

Objective To explore the therapeutic effect of Shenling Baizhu Granules combined with Compound Pancreatin in treatment of functional dyspepsia in children. Methods A total of 96 children with functional dyspepsia who received treatment in the First Hospital of Yulin from August 2022 to December 2023 were selected and divided into control group and treatment group according to random number table method, with 48 cases in each group. Patients in the control group were po administered with Compound Pancreatin, 2 bags/time, three times daily. Patients in the treatment group were po administered with Shenling Baizhu Granules on the basis of the control group, 3 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacy was evaluated, the clinical efficacy and disappearance time of traditional Chinese medicine symptoms of two groups were observed, and the changes of gastric emptying rate, motilin and calcitonin gene-related peptide (CGRP) before and after treatment were compared between the two groups. Results After treatment, the total effective rate of treatment group was 95.83%, which was significantly higher than that of control group (83.33%, P < 0.05). After treatment, compared with control group, the disappearance time of epigastric fullness, less food and dull stomach pain was shorter in treatment group (P < 0.05). After treatment, the gastric emptying rate of 30 and 60 min after meal was significantly increased in both groups (P < 0.05). After treatment, the gastric empting rate 30 and 60 min after meal in treatment group was higher than that in control group (P < 0.05). After treatment, the serum motilin level was significantly increased and the serum CGRP level was significantly decreased in both groups (P < 0.05). Compared with the control group, the serum motilin level in treatment group was higher and the serum CGRP level was lower (P < 0.05). Conclusion Shenling Baizhu Granules combined with Compound Pancreatin can obtain better treatment effect in treatment of functional dyspepsia in children, and can effectively improve gastric emptying delay, serum motilin and CGRP levels with high safety.

R985；R975

陕西省科技计划项目（2021SF-040）