目的 探讨热毒宁注射液联合注射用头孢唑林钠治疗急性支气管炎的临床疗效。方法 选取2022年3月—2024年2月宜兴市人民医院收治的80例急性支气管炎患者，将所有患者按照随机数字表法分为对照组和治疗组，40例/组。对照组静脉滴注注射用头孢唑林钠，2次/d，1 g/次，加入200 mL生理盐水。治疗组在对照组基础上滴注热毒宁注射液，1次/d，20 mL/次，溶于250 mL生理盐水。两组患者持续治疗7 d。比较两组的临床疗效、症状缓解时间、咳嗽频率、咳嗽程度、小气道功能指标和血清指标。结果 治疗后，治疗组的总有效率为97.50%，对照组的总有效率为82.50%，组间比较差异有统计学意义（P＜0.05）。治疗后，治疗组患者高热、气喘、咳嗽、咯痰缓解时间均短于对照组，差异有统计学意义（P＜0.05）。治疗后，两组的咳嗽频率、简易咳嗽程度量表（CET）评分均低于治疗前（P＜0.05），且治疗组患者的咳嗽频率、CET评分低于对照组（P＜0.05）。治疗后，两组的用力呼气50%肺活量时的瞬间流量（FEF_50%）、用力呼出气量为25%～75%肺活量间的平均流量（FEF_25%-75%）、呼气高峰流量（PEFR）明显高于治疗前（P＜0.05）；治疗组的FEF_50%、FEF_25%-75%、PEFR高于对照组（P＜0.05）。治疗后，两组的血清标本淀粉样蛋白A（SAA）、C反应蛋白（CRP）、降钙素原（PCT）、免疫球蛋白M（IgM）水平均显著下降（P＜0.05），且治疗组血清SAA、CRP、PCT、IgM水平比对照组下降更明显（P＜0.05）。结论 热毒宁注射液联合注射用头孢唑林钠可提高急性支气管炎的疗效，缓解临床症状，减轻咳嗽，改善小气道功能，降低炎症反应。

Objective To investigate the clinical efficacy of Reduning Injection combined with Cefazolin Sodium for injection in treatment of acute bronchitis. Methods A total of 80 patients with acute bronchitis admitted to Yixing People’s Hospital from March 2022 to February 2024 were selected and divided into control group and treatment group according to random number table method, with 40 cases/group. Patients in the control group were iv Cefazolin Sodium for injection, twice daily, 1 g/time, and 200 mL normal saline was added. On the basis of the control group, patients in the treatment group were iv Reduning Injection, once daily, 20 mL/time, dissolved in 250 mL normal saline. Both groups were treated for 7 d. The therapeutic effect, symptom remission time, cough frequency, cough degree, small airway function index, and serum index were compared between two groups. Results After treatment, the total effective rate of the treatment group was 97.50%, the total effective rate of the control group was 82.50%, and the difference between groups was statistically significant (P < 0.05). After treatment, the remission time of hyperthermia, asthma, cough, and phlegm in the treatment group was shorter than that in the control group, and the difference was statistically significant (P < 0.05). After treatment, the cough frequency and CET scores of two groups were lower than these before treatment (P < 0.05), and the cough frequency and CET scores of the treatment group were lower than those of the control group (P < 0.05). After treatment, FEF_50%, FEF_25%-75%, and PEFR in two groups were significantly higher than these before treatment (P < 0.05). FEF_50%, FEF_25%-75%, and PEFR in the treatment group were higher than those in the control group (P < 0.05). After treatment, the levels serum of SAA, CRP, PCT, and IgM in two groups were significantly decreased (P < 0.05), and the levels serum of SAA, CRP, PCT, and IgM in the treatment group were more significantly decreased than those in the control group (P < 0.05). Conclusion Reduning Injection combined with Cefazolin Sodium for injection can improve the curative effect of acute bronchitis, relieve clinical symptoms, relieve cough, improve small airway function and reduce inflammation.

R974

宜兴市科技（社会发展）项目（2019SF21）