银屑病是一种慢性自身免疫性皮肤病，其核心是免疫反应失调和角质形成细胞增殖异常。核因子-κB（NF-κB）在银屑病中是一种关键的调节信号通路，通过抑制NF-κB信号途径或下游转录因子肿瘤坏死因子-α（TNF-α）或白细胞介素-17（IL-17）/白细胞介素-23（IL-23）成为未来银屑病治疗的一个新方向。中药针对NF-κB信号通路在银屑病治疗中具有疗效确切、手段多样、不良反应小等优势。总结了中药调控丝裂原活化蛋白激酶（MAPK）/NF-κB、NF-κB/信号传导和转录激活因子3（STAT3）、Toll样受体4（TLR4）/NF-κB信号通路治疗银屑病的研究进展，以期为中药治疗银屑病提供更新策略。

Psoriasis is a chronic autoimmune skin disease, characterized by immune dysfunction and abnormal proliferation of keratinocytes at its core. NF-κB is a key regulatory signaling pathway in psoriasis, and inhibiting the NF-κB signaling pathway or downstream transcription factors such as TNF-α or IL-17/IL-23 has become a new direction for future psoriasis treatment. Traditional Chinese medicine targeting the NF-κB signaling pathway has the advantages of definite therapeutic effect, diverse methods, and minimal adverse reactions in treatment of psoriasis. This article summarizes the research progress on traditional Chinese medicine in treatment of psoriasis by regulating MAPK/NF-κB, NF-κB/STAT3, and TLR4/NF-κB signaling pathways, with the aim of providing updated strategies for the treatment of psoriasis with traditional Chinese medicine.

R986

国家自然科学基金资助项目（81973846）