目的 探讨新癀片联合盐酸米诺环素软膏治疗智齿冠周炎的临床疗效。方法 选取2021年3月—2024年2月在天津市职业病防治院就诊的88例智齿冠周炎患者，按随机数字表法分为对照组和治疗组，每组各44例。对照组将盐酸米诺环素软膏注满患处的牙周袋内，1次/周。治疗组在对照组基础上口服新癀片，3次/d，3片/次。两组患者持续治疗4周。比较两组的临床疗效、症状消失时间、主观牙痛程度、牙龈指数和血清炎性指标。结果 治疗组的治愈率为95.45%，对照组的治愈率为81.82%，组间差异显著（P＜0.05）。治疗后，治疗组患者牙齿肿胀、牙齿疼痛、张口受限、发热消失时间均短于对照组（P＜0.05）。治疗后，两组的视觉模拟法（VAS）评分、牙龈指数、血清超敏C反应蛋白（hs-CRP）、前列腺素E₂（PGE₂）水平均低于治疗前，血清白细胞介素-2（IL-2）水平高于治疗前（P＜0.05）；治疗组的VAS评分、牙龈指数、血清hs-CRP、PGE₂水平比对照组低，血清IL-2水平高于对照组（P＜0.05）。结论 新癀片联合盐酸米诺环素软膏可提高智齿冠周炎的治疗效果，改善临床症状，减轻疼痛程度，改善牙龈状态，降低炎症反应。

Objective To explore the clinical efficacy of Xinhuang Tablets combined with Minocycline Hydrochloride Ointment in treatment of wisdom tooth periodontitis. Methods Patients (88 cases) with wisdom tooth pericoronitis treated in Tianjin Occupational Disease Prevention and Therapeutic Hospital from March 2021 to February 2024 were selected and divided into control group and treatment group according to random number table method, with 44 cases in each group. Patients in the control group was filled with Minocycline Hydrochloride Ointment in the periodontal pocket of the affected area, once weekly. In the treatment group, Xinhuang Tablets was taken orally, three times daily, 3 tablets/times on the basis of the control group. Patients of two groups were treated for 4 weeks. The clinical efficacy, symptom disappearance time, subjective toothache degree, gingival index, and serum inflammatory indicators between two groups were compare. Results The cure rate was 95.45% in the treatment group, 81.82% in the control group, and the difference between the two groups was significant (P < 0.05). After treatment, the disappearance times of tooth swelling, tooth pain, mouth opening restriction and fever in the treatment group was shorter than those in the control group (P < 0.05). After treatment, VAS scores, gingival index, and serum levels of hs-CRP and PGE₂ of two groups were lower than those before treatment, but the serum levels of IL-2 were higher than those before treatment (P < 0.05). VAS score, gingival index, and hs-CRP and PGE₂ serum levels in the treatment group were lower than those in the control group, but serum levels of IL-2 in treatment group were higher than those in control group (P < 0.05). Conclusion Xinhuang Tablets combined with Minocycline Hydrochloride Ointment can improve the effect of wisdom tooth pericoronitis, improve clinical symptoms, reduce pain, improve gingival state, and reduce inflammation.

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