目的 探讨健脾生血片联合复方硫酸亚铁颗粒治疗妊娠期缺铁性贫血的临床疗效。方法 选取2021年10月—2023年10月在延安大学咸阳医院治疗的妊娠期缺铁性贫血患者106例，按照随机数表法分为对照组（53例）和治疗组（53例）。对照组饭后口服复方硫酸亚铁颗粒，1袋/次，1次/d。治疗组在对照组基础上饭后口服健脾生血片，3片/次，3次/d。两组患者连续治疗4周。观察两组患者临床疗效，比较治疗前后两组患者中医症状改善时间及血红蛋白（Hb）、红细胞计数、红细胞比容、铁调素、铁蛋白和总铁结合力水平。结果 治疗后，治疗组总有效率为94.34%，与对照组的81.13%比较明显升高（P＜0.05）。与对照组比较，治疗后治疗组体倦乏力、食欲不振、面色萎黄改善时间明显缩短（P＜0.05）。与治疗前比较，两组Hb、红细胞计数、红细胞比容、铁调素、铁蛋白水平均明显升高，而总铁结合力水平明显降低（P＜0.05），且与对照组治疗后比较，治疗组患者改善更明显（P＜0.05）。结论 健脾生血片联合复方硫酸亚铁颗粒治疗妊娠期缺铁性贫血可获得较好的临床效果，能有效改善患者的中医症状、红细胞相关指标以及铁代谢。

Objective To explore the therapeutic effect of Jianpi Shengxue Tablets combined with compound ferrous sulfate in treatment of iron deficiency anemia during pregnancy. Methods Patients (106 cases) with iron deficiency anemia during pregnancy in Yan'an University Xianyang Hospital from October 2021 to October 2023 were divided into control group (53 cases) and treatment group (53 cases) according to random number table method. Patients in the control group were po administered with Compound Ferrous Sulfate Granules after meals, 1 bag/time, once daily. Patients in the treatment group were po administered with Jianpi Shengxue Tablets on the basis of the control group, 3 tablets/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, the improvement time for TCM symptoms, the levels of Hb, red blood cell count, hematocrit, hepcidin, ferritin and total iron binding capacity in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 94.34%, which was significantly higher than that of the control group (81.13%, P < 0.05). Compared with the control group, the improvement time of fatigue, loss of appetite and sallow complexion in the treatment group was significantly shorter than that in the control group (P < 0.05). Compared with before treatment, the levels of Hb, red blood cell count, hematocrit, ferritin were significantly increased, while the total iron binding capacity were significantly decreased in two groups (P < 0.05), and compared with the control group, the improvement in the treatment group of there indexes was more obvious (P < 0.05). Conclusion Jianpi Shengxue Tablets combined with compound ferrous sulfate in treatment of iron deficiency anemia during pregnancy can obtain better clinical effect, and effectively improve the TCM symptoms, erythrocyte related indexes and iron metabolism of patients.

R984

陕西省科技计划项目（2019SF-050）