目的 探讨全杜仲胶囊联合阿仑膦酸钠治疗老年骨质疏松症的临床疗效。方法 选择2020年3月—2023年8月在西电集团医院治疗的98例老年骨质疏松症患者，根据随机数表法分为对照组（49例）和治疗组（49例）。对照组早餐前30 min口服阿仑膦酸钠片，10 mg/次，1次/d。治疗组在对照组基础上口服全杜仲胶囊，2粒/次，2次/d。两组均治疗3个月。观察两组患者临床疗效，比较治疗前后两组患者中医症状改善时间，骨代谢指标Ⅰ型胶原交联C端肽（CTX）、肿瘤坏死因子-α（TNF-α）和尿Ⅰ型胶原交联N端肽（NTX）水平，及骨密度水平。结果 治疗后，治疗组总有效率为95.92%，比对照组的81.63%明显升高（P＜0.05）。与对照组比较，治疗组患者食少便溏、腰膝冷痛、畏寒喜暖、腰膝酸软改善时间明显缩短（P＜0.05）。与治疗前比较，两组血清CTX、TNF-α及NTX水平明显降低（P＜0.05），且治疗组血清CTX、TNF-α和NTX水平更低（P＜0.05）。与治疗前比较，两组股骨颈、腰椎等部位的骨密度均升高（P＜0.05），且与对照组比较，治疗组骨密度更高（P＜0.05）。结论 全杜仲胶囊联合阿仑膦酸钠治疗老年骨质疏松症可快速改善患者的中医症状、增加骨密度水平、有效调节骨代谢指标。

Objective To explore the therapeutic effect of Quanduzhong Capsules combined with alendronate sodium in treatment of elderly osteoporosis. Methods Patients (98 cases) with elderly osteoporosis in XD Group Hospital from March 2020 to August 2023 were divided into control (49 cases) and treatment (49 cases) group according to the random number table method. Patients in the control group were po administered with Alendronate Sodium Tablets 30 min before breakfast, 10 mg/time, once daily. Patients in the treatment group were po administered with Quanduzhong Capsules on the basis of the control group, 2 grains/time, twice daily. Patients in two groups were treated for 3 months. After treatment, the clinical evaluations were evaluated, the improvement time of TCM symptoms, the levels of bone metabolism indicators CTX, TNF-α and NTX, and bone density levels in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 95.92%, which was significantly higher than that of the control group (81.63%, P < 0.05). Compared with the control group, the improvement time of loose stool, cold pain of waist and knees, fear of cold and warmth, sore waist and knees in the treatment group was significantly shorter than that in the control group (P < 0.05). The levels of serum CTX, TNF-α and NTX in two groups were significantly lower than those before treatment (P < 0.05), and the levels of serum CTX, TNF-α and NTX in the treatment group were lower than those before treatment (P < 0.05). Compared with those before treatment, the bone mineral density of femoral neck and lumbar vertebrae in two groups was significantly increased (P < 0.05), and the bone mineral density in the treatment group was higher than that in the control group (P < 0.05). Conclusion Quanduzhong Capsules combined with alendronate sodium combined with alendronate can quickly improve the TCM symptoms, increase the level of bone mineral density and effectively regulate bone metabolism.

R982

陕西省卫生健康科研项目（2022D017）