目的 探讨降糖通脉胶囊联合利拉鲁肽注射液对2型糖尿病的治疗效果。方法 选取2022年7月—2023年7月联勤保障部队第九八七医院收治的2型糖尿病患者98例，根据随机数表法分为对照组（49例）和治疗组（49例）。对照组患者给予利拉鲁肽注射液，起始剂量0.6 mg/d，若血糖控制效果不理想则适当增加剂量，最大不超过1.8 mg/d。治疗组患者在对照组基础上口服降糖通脉胶囊，3粒/次，3次/d。两组患者均治疗12周。观察两组患者临床疗效，比较治疗前后两组患者中医症状积分，及餐后2 h血糖（2 h PBG）、空腹血糖、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）水平。结果 治疗后，治疗组总有效率为95.92%，比对照组的83.67%明显升高（P＜0.05）。治疗后，两组倦怠乏力、口渴喜饮、气短懒言、多食易饥评分均明显降低（P＜0.05），且治疗组的各项评分均低于对照组（P＜0.05）。治疗后，两组餐后2 h血糖（2 h PPG）、空腹血糖、糖化血红蛋白（HbA1c）、胰岛素抵抗指数（HOMA-IR）水平均明显降低（P＜0.05），且治疗组的各项血糖指标均低于对照组（P＜0.05）。结论 在利拉鲁肽注射液的基础上联用降糖通脉胶囊治疗2型糖尿病疗效较为理想，能有效改善患者的中医症状、控制体内血糖水平，降低胰岛素抵抗。

Objective To investigate the therapeutic effect of Jiangtang Tongmai Capsules combined with lilalutide in treatment of type 2 diabetes. Methods Patients (98 cases) with type 2 diabetes in the Joint Logistics Support Force 987th Hospital from July 2022 to July 2023 were divided into control (49 cases) and treatment (49 cases) group according to the random number table method. Patients in control group were administered with Liraglutide Injection, the initial dose was 0.6 mg/d, and if the effect of blood glucose control was not ideal, the dose should be increased appropriately, and the maximum was not more than 1.8 mg/d. Patients in the treatment group were po administered with Jiangtang Tongmai Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 12 weeks. After treatment, the clinical evaluations were evaluated, the TCM symptom scores, and the levels of 2 h PBG, fasting blood glucose, HbA1c and HOMA-IR in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 95.92%, which was significantly higher than that of the control group (83.67%, P < 0.05). After treatment, the scores of fatigue, thirst and drinking, shortness of breath and lazy talk, overeating and hunger were significantly decreased in two groups (P < 0.05), and the scores in the treatment group were lower than those in the control group (P < 0.05). After treatment, the levels of 2 h postprandial blood glucose (2 h PBG), fasting blood glucose, glycosylated hemoglobin (HbA1c) and insulin resistance index (HOMA-IR) were significantly decreased in two groups, and the blood glucose indexes in the treatment group were lower than those in the control group (P < 0.05). Conclusion On the basis of Liraglutide Injection, Jiangtang Tongmai Capsules is effective in the treatment of type 2 diabetes, which can effectively improve the symptoms of traditional Chinese medicine, control the level of blood glucose and reduce insulin resistance.

R977

陕西省科技计划项目（2020SF-122）