肾脏疾病可造成肾组织不同程度的损伤，导致肾功能下降。丹参酮Ⅱ_A是从丹参中分离得到的脂溶性二萜醌，具有多种药理作用，可通过减轻炎症反应，减轻氧化应激反应，延缓肾组织纤维化，抑制细胞凋亡，增强细胞自噬，改善血液流变学，促进有害物质外流对肾功能发挥保护作用。总结了丹参酮Ⅱ_A治疗肾损伤的药理作用研究进展，为丹参酮Ⅱ_A在肾脏疾病中临床应用提供参考。

Kidney disease can cause varying degrees of damage to renal tissue, leading to a decrease in renal function. Tanshinone II_A is a lipid soluble diterpenoid quinone isolated from Salviae Miltiorrhizae Radix etRhizoma, which has various pharmacological effects. Tanshinone II_A can alleviate inflammation response, reduce oxidative stress reaction, delay renal tissue fibrosis, reduce cell apoptosis, enhance cell autophagy, improve hemorheology, and promote the efflux of harmful substances, thus it play a protective role in renal function. This article summarizes the pharmacological research progress of tanshinone II_A in treatment of kidney injury, providing reference for the clinical application of tanshinone II_A in kidney diseases.

R965

卫生健康发展促进项目（KM-MXQD-002）