肺部感染临床常以肺炎形式存出现，治疗核心为抗感染，但多数病原菌对传统药物具有较高的耐药性。小檗碱是从黄连中提取的活性成分，具有多种活性，可通过降低病原菌耐药性，阻止病原菌复制，减轻肺部炎症反应，调节免疫功能，抑制肺纤维化进程，保护血管内皮细胞以治疗肺部感染，减轻肺组织损伤。综述了小檗碱用于肺部感染治疗的药理作用研究进展，为小檗碱临床治疗肺部感染提供依据。

Pulmonary infections often occur in the form of pneumonia in clinical practice, and the core treatment is anti-infection. However, most pathogens have high resistance to traditional drugs. Berberine is an active ingredient extracted from Coptidis Rhizoma, which has various activities. Berberine can reduce pathogen resistance, prevent pathogen replication, alleviate pulmonary inflammatory response, regulate immune function, inhibit pulmonary fibrosis process, and protect vascular endothelial cells, so as to treat lung infection and reduce lung tissue damage. This article reviews the pharmacological research progress of berberine in treatment of pulmonary infections, providing a basis for the clinical treatment of pulmonary infections with berberine.

R965;R974

重庆市科卫联合医学科研项目（2019ZDXM042）