目的 对亳州市人民医院纳洛酮使用进行合理性评价，促进临床合理使用纳洛酮。方法 以纳洛酮说明书为基础，结合相关指南、专家共识及文献，建立纳洛酮药物利用评价（DUE）细则，并以此为依据，运用属性层次模式的方法对亳州市人民医院2023年1月1日—2023年12月1日纳洛酮的使用情况进行合理性评价。结果 在评价的151份病历中，优秀病历占比2.65%，良好病历28.48%，合格64.90%，不合格3.97%，不合理应用主要表现在适应证不合理、用量不合理、疗程不合理和无用药监测。结论 评价结果反映纳洛酮在临床使用中存在的不合理现象，需进一步加强管控。

Objective To evaluate the rationality of naloxone use in Bozhou People’s Hospital, and promote the rational use of naloxone in clinical practice. Methods The naloxone drug utilization evaluation (DUE) rules were established based on the naloxone instruction manual, combined with related guidelines, expert consensus and literature. Based on this, the use of naloxone in Bozhou People’s Hospital from January 1, 2023 to December 1, 2023 was rationally evaluated by using attribute hierarchy model. Results Among the 151 medical records evaluated, excellent medical records accounted for 2.65%, good medical records 28.48%, qualified 64.90%, and unqualified 3.97%. Irrational use was mainly manifested in unreasonable indications, unreasonable dosage, unreasonable course of treatment, and no drug monitoring. Conclusion The evaluation results reflect the unreasonable phenomenon in the clinical use of naloxone, which needs to be further strengthened.

R971

安徽省高等学校科学研究项目（自然科学类）（2023AH053213）