目的 探讨口炎清颗粒联合更昔洛韦片治疗疱疹性口炎的临床疗效。方法 选取天津市黄河医院在2021年6月—2023年7月收治的92例疱疹性口炎患者，按照随机数字法将所有患者分为对照组和治疗组，每组各46例。对照组口服更昔洛韦片，2片/次，3次/d。治疗组患者在对照组治疗基础上口服口炎清颗粒，2袋/次，2次/d。两组患者持续治疗7 d。比较两组的临床疗效、症状消失时间、口腔黏膜病损面积、主观疼痛程度和血清因子。结果 治疗后，治疗组总有效率为93.48%，对照组总有效率为76.09%，组间比较差异显著（P＜0.05）。治疗后，治疗组患者的发热、流涎、拒食、疱疹消失时间均明显短于对照组，组间差异显著（P＜0.05）。治疗后，两组患者的口腔黏膜病损面积、视觉模拟评分法（VAS）评分均比治疗前小（P＜0.05），治疗组口腔黏膜病损面积、VAS评分比对照组更小（P＜0.05）。治疗后，两组单纯疱疹病毒-免疫球蛋白M（HSV-IgM）、单纯疱疹病毒-免疫球蛋白G（HSV-IgG）阳性率均显著下降（P＜0.05）；治疗组HSV-IgM、HSV-IgG的阳性率均低于对照组（P＜0.05）。治疗后，两组的血清白细胞介素-6（IL-6）、C反应蛋白（CRP）水平低于治疗前（P＜0.05），且治疗组的血清IL-6、CRP水平低于对照组（P＜0.05）。结论 口炎清颗粒联合更昔洛韦片可提高疱疹性口炎的临床疗效，减轻临床症状和疼痛程度，缩小病损面积，减轻炎症反应。

Objective To investigate the clinical effect of Kouyanqing Granules combined with Ganciclovir Tablets in treatment of herpetic stomatitis. Methods Patients (92 cases) with herpetic stomatitis in Tianjin Yellow River Hospital from June 2021 to July 2023 were divided into control and treatment groups according to the random number method, and each group had 46 cases. Patients in the control group were po administered with Ganciclovir Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Kouyanqing Granules on the basis of the control group, 2 bags/time, twice daily. Patients in two groups were treated for 7 d. The clinical efficacies, the disappearance time of the main symptoms, the change of the area of the oral mucosal lesion, the subjective pain degree, serum factors in two groups were compared. Results After treatment, the total effective rate of the treatment group was 93.48%, while the total effective rate of the control group was 76.09%, with a significant difference between two groups (P < 0.05). After treatment, the disappearance times of fever, drooling, refusal to eat, and herpes in the treatment group was significantly shorter than that in the control group, with significant differences between the groups (P < 0.05). After treatment, the area of oral mucosal lesions and VAS scores in two groups were smaller than those before treatment (P < 0.05), and the area of oral mucosal lesions and VAS scores in the treatment group were smaller than those in the control group (P < 0.05). After treatment, the positive rates of HSV-IgM and HSV-IgG in two groups significantly decreased (P < 0.05); the positive rates of HSV-IgM and HSV-IgG in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of IL-6 and CRP in two groups were lower than before treatment (P < 0.05), and the serum levels of IL-6 and CRP in the treatment group were lower than those in the control group (P < 0.05). Conclusion Kouyanqing Granules combined with Ganciclovir Tablets can improve the curative effect in treatment of herpetic stomatitis, further reduce the clinical symptoms and pain, reduce the area of lesion, and reduce inflammation.

R988.2

河北省中医药管理局科研计划项目（2019447）