目的 探讨芩香清解口服液联合磷酸奥司他韦颗粒治疗儿童上呼吸道感染的临床疗效。方法 选取哈尔滨医科大学附属第六医院2021年6月—2022年6月收治的124例上呼吸道感染患儿，采用随机数字表法将所有患儿分为对照组（62例）和治疗组（62例）。对照组患儿口服磷酸奥司他韦颗粒，2次/d，体质量≤15 kg，30 mg/次；23 kg≥体质量＞15 kg，45 mg/次；40 kg≥体质量＞23 kg，60 mg/次；体质量＞40 kg，75 mg/次。治疗组在对照组基础上口服芩香清解口服液，3岁≤患儿年龄＜7岁，10 mL/次；7岁≤患儿年龄＜14岁，15 mL/次；3次/d。两组均治疗1周。比较两组的临床疗效、临床症状、炎症因子。结果 治疗后，治疗组的总有效率为91.94%，高于对照组的总有效率79.03%（P＜0.05）。与对照组相比，治疗组的咽喉肿痛、发热、流鼻涕、肺啰音、咳嗽、乏力消失时间更短（P＜0.05）。治疗后，两组患儿血清C反应蛋白（CRP）、白细胞介素-1β（IL-1β）、可溶性白细胞介素-2受体（SIL-2R）、淀粉样蛋白A（SAA）水平下降，γ干扰素（IFN-γ）水平升高（P＜0.05）。与对照组相比，治疗组血清CRP、IL-1β、SIL-2R、SAA水平更低，IFN-γ水平更高（P＜0.05）。结论 芩香清解口服液联合磷酸奥司他韦颗粒可用于治疗儿童上呼吸道感染，提高机体免疫力，改善患儿血清炎症因子水平。

Objective To explore the clinical efficacy of Qinxiang Qingjie Oral Liquid combined with Oseltamivir Phosphate Granules in treatment of upper respiratory tract infections in children. Methods Children (124 cases) with upper respiratory tract infections in Jiangnan Campus of the Sixth Affiliated Hospital of Harbin Medical University from June 2021 to June 2022 were divided into the control group (62 cases) and the treatment group (62 cases) using the random number table method. Children in the control group were po administered with Oseltamivir Phosphate Granules, weight ≤ 15 kg, 30 mg; 23 kg ≥ weight >15 kg, 45 mg; 40 kg ≥ weight > 23 kg, 60 mg; weight > 40 kg, 75 mg; twice daily. Children in the treatment group were po administered with Qinxiang Qingjie Oral Liquid on the basis of the control group, 3 — 7 years old, 10 mL/time; 7 — 14 years old, 15 mL/time; three times daily. Children in two groups were treated for 1 week. The clinical efficacies, the clinical symptoms, and inflammatory factor indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 91.94%, which was higher than 79.03% of the control group (P < 0.05). Compared with the control group, the disappearance time of sore throat, fever, runny nose, lung rales, cough, and fatigue in the treatment group was shorter (P< 0.05). After treatment, the serum levels of CRP, IL-1β, SIL-2R, and SAA in two groups were decreased, but the serum levels of IFN-γ in two groups were increased (P < 0.05). Compared with the control group, the levels of CRP, IL-1β, SIL-2R, and SAA in the treatment group were lower, but the levels of IFN-γ were higher (P < 0.05). Conclusion Qinxiang Qingjie Oral Liquid combined with Oseltamivir Phosphate Granules can be used to treat upper respiratory tract infections in children, improve the body’s immunity, and improve the serum inflammatory factor levels in children.

R974;R985

黑龙江省自然科学基金资助项目（A20200451）