骨性关节炎是以软骨细胞去分化、软骨退化和软骨缺损为特征的致残性疾病，目前尚缺乏有效的药物，临床治疗以延缓病情为主。丹参酮ⅡA是丹参中脂溶性成分，具有多种药理作用，可降低炎症反应、保护软骨组织以防治骨性关节炎。综述了丹参酮ⅡA防治骨性关节炎的研究进展，总结其作用机制，为丹参酮Ⅱ_A临床治疗骨性关节炎提供参考。

Osteoarthritis is a disabling disease characterized by dedifferentiation of chondrocytes, cartilage degeneration, and cartilage defects. At present, there is a lack of effective drugs, and clinical treatment mainly focuses on alleviating symptoms. Tanshinone Ⅱ_A is a lipophilic component from Salviae Miltiorrhizae Radix et Rhizoma, which has multiple pharmacological effects. Tanshinone Ⅱ_A can reduce inflammation and protect cartilage tissue to prevent and treat osteoarthritis. This article summarizes the research progress of tanshinone Ⅱ_A in prevention and treatment of osteoarthritis, summarizes its mechanism, and provides reference for the clinical treatment of osteoarthritis with tanshinone Ⅱ_A.

R285；R982

重庆市大足区科技发展项目（DZKJ2023JSYJ-KWXM1042）