心血管疾病已成为威胁人类健康的最主要疾病，其中动脉粥样硬化是心血管疾病的主要原因和病理基础。大黄素是从大黄、虎杖中获得的蒽醌衍生物，具有多种药理作用。大黄素可通过降低炎症反应、降低氧化应激反应、调节脂质代谢、阻止血管平滑肌增殖、保护血管内皮功能、稳定动脉粥样硬化斑块等多种途径对动脉粥样硬化发挥防治作用。综述了大黄素防治动脉粥样硬化的作用机制研究进展，为大黄素防治动脉粥样硬化的临床应用提供参考。

Cardiovascular disease has become the most important disease threatening human health, and atherosclerosis is the main cause and pathological basis of cardiovascular disease. Emodin is an anthraquinone derivative obtained from Rhei Radix et Rhizoma and Polygoni Cuspidati Rhizoma, which has various pharmacological effects. Emodin can prevent and treat atherosclerosis by reducing inflammatory reaction, reducing oxidative stress reaction, regulating lipid metabolism, preventing vascular smooth muscle proliferation, protecting vascular endothelial function, stabilizing atherosclerotic plaque. This article reviews the research progress of mechanism of emodin in prevention and treatment of atherosclerosis, which provides a reference for the clinical application of emodin in prevention and treatment of atherosclerosis.

R285；R973