哺乳动物雷帕霉素靶蛋白（mTOR）与癌症有密切关系，抑制mTOR通路可以发挥抗肿瘤作用。目前许多mTOR抑制剂被开发用于癌症的治疗。一些中药活性成分如蒽醌类、生物碱类、萜类、多糖类、黄酮类、多酚类成分可以通过抑制mTOR通路诱导肿瘤细胞凋亡、促进自噬、阻断细胞周期发挥抗肿瘤作用。总结了中药活性成分抑制mTOR通路抗肿瘤作用的研究进展，明确其作用机制，为临床应用提供参考。

Mammalian target of rapamycin (mTOR) is closely related to cancer, and inhibiting the mTOR pathway can exert anti-tumor effects. At present, many mTOR inhibitors are being developed for the treatment of cancer. Some active ingredients in traditional Chinese medicine, such as anthraquinone, alkaloids, terpenoids, polysaccharides, flavonoids, polyphenols, can exert anti-tumor effects by inhibiting the mTOR pathway through inducing tumor cell apoptosis, promoting autophagy, and blocking the cell cycle. This article summarizes the research progress on anti-tumor effects of active ingredients in traditional Chinese medicine through the mTOR pathway, clarifies their mechanisms of action, and provides reference for clinical applications.

R285；R972

国家自然科学基金面上项目（81972847）;天津市自然科学基金多元投入基金资助项目（21JCYBJC01830）;天津市医学重点学科（专科）建设项目资助（TJYXZDXK-053B）;天津市人民医院院级课题（2022ZLXK01，2022ZLXK07）