目的 探讨金骨莲胶囊联合右旋酮洛芬氨丁三醇片治疗风湿痹阻型类风湿关节炎的疗效。方法 选取2022年1月—2022年12月山西医科大学附属运城市中心医院收治的类风湿关节炎患者100例，根据治疗方案不同将患者分为对照组（50例）和治疗组（50例）。对照组患者口服右旋酮洛芬氨丁三醇片，12.5 mg/次，3次/d。治疗组在对照组基础上口服金骨莲胶囊，5粒/次，3次/d。两组患者均持续治疗4周。观察两组患者临床疗效，比较治疗前后两组患者中医证候积分、肿胀关节数、压痛关节数，及红细胞沉降率（ESR）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平。结果 治疗后，治疗组总有效率显著优于对照组（98.00% vs 86.00%，P＜0.05）。治疗后，两组患者中医证候积分、肿胀关节数、压痛关节数及ESR、TNF-α、IL-6水平比治疗前显著降低（P＜0.05），且治疗组明显低于对照组（P＜0.05）。结论 金骨莲胶囊联合右旋酮洛芬氨丁三醇片治疗风湿痹阻型类风湿关节炎疗效及安全性均较高，能有效降低患者炎性水平，减轻关节疼痛及改善中医证候。

Objective To explore the treatment of Jingulian Capsules combined with Dexketoprofen Trometamol Tablets in treatment of rheumatoid arthritis of rheumatic obstruction type. Methods Patients (100 cases) with rheumatoid arthritis of rheumatic obstruction type in Yuncheng Central Hospital affiliated to Shanxi Medical University from January 2022 to December 2022 were divided into control (50 cases) and treatment (50 cases)group according different drug use. Patients in the control group were po administered with Dexketoprofen Trometamol Tablets, 12.5 mg/time, three times daily. Patients in the treatment group were po administered with Jingulian Capsule on the basis of the control group, 5 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical evaluations were evaluated, the TCM syndrome score, number of swollen joints and tender joints, the levels of ESR, TNF-α and IL-6 in two groups before and after treatment were compared. Results After treatment, the clinical effect of the treatment group was significantly better than that of the control group (98.00% vs 86.00%, P < 0.05). After treatment, the scores of TCM syndrome, the number of swollen joints, the number of tenderness joints and the levels of ESR, TNF-α and IL-6 in two groups were significantly lower than those before treatment (P < 0.05), and which in the treatment group were significantly lower than those in the control group (P < 0.05). Conclusion Jingulian Capsules combined with Dexketoprofen Trometamol Tablets has high efficacy and safety in the treatment of rheumatoid arthritis, which can effectively reduce the inflammatory level of patients, reduce joint pain and improve TCM syndromes.

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