目的 探讨神曲消食口服液联合乳酸菌素片治疗小儿功能性消化不良的临床疗效。方法 选取2022年4月—2023年6月北京市大兴区人民医院收治的104例功能性消化不良患儿，采用随机数表法将患儿分为对照组（52例）和治疗组（52例）。对照组嚼服乳酸菌素片，患儿＜5岁，0.4 g/次；患儿≥5岁，0.8 g/次，3次/d。治疗组在对照组治疗基础上口服神曲消食口服液，患儿＜5岁，5 mL/次；患儿≥5岁，10 mL/次，3次/d。两组均连续治疗2周。观察两组的临床疗效和中医症状改善时间，比较两组治疗前后功能性消化不良生存质量量表（FDDQL）评分及血清胃动素、神经肽Y水平。结果 治疗后，治疗组总有效率为96.15%，显著高于对照组的84.62%（P＜0.05）。治疗后，治疗组食少纳呆、脘腹痞闷、脘腹胀痛的改善时间均显著短于对照组（P＜0.05）。治疗后，两组FDDQL评分均高于治疗前（P＜0.05）；且治疗组的FDDQL评分高于对照组（P＜0.05）。治疗后，两组胃动素、神经肽Y水平均高于治疗前（P＜0.05）；且治疗后，治疗组胃动素、神经肽Y水平高于对照组（P＜0.05）。结论 神曲消食口服液联合乳酸菌素片治疗小儿功能性消化不良具有较好的治疗效果，可改善患儿的中医症状、生活质量及消化功能，并增加患儿食欲，且无明显不良反应。

Objective To explore the efficacy of Shenqu Xiaoshi Oral Liquid combined with lacidophilin in treatment of functional dyspepsia in children. Methods A total of 104 children with functional dyspepsia treated in Daxing District People's Hospital of Beijing from April 2022 to June 2023 were selected and divided into control group (52 cases) and treatment group (52 cases) by random number table method. Children in control group chewed Lacidophilin Tablets, children < 5 years old, 0.4 g/time, children ≥ 5 years old, 0.8 g/time, 3 times daily. Children in treatment group were po administered with Shenqu Xiaoshi Oral Liquid on the basis of control group, children < 5 years old, 5 mL/time, children ≥ 5 years old, 10 mL/time, 3 times daily. Both groups were treated continuously for 2 weeks. The clinical efficacy and the improvement time of traditional Chinese medicine symptoms of two groups were observed, and the scores of functional dyspepsia life Quality Scale (FDDQL), serum motilin and neuropeptide Y levels were compared between two groups before and after treatment. Results After treatment, the total effective rate of treatment group was 96.15%, which was significantly higher than that of control group (84.62%, P < 0.05). After treatment, the improvement time of food deficiency, abdominal fullness, and abdominal distension pain in treatment group was significantly shorter than that in control group (P < 0.05). After treatment, FDDQL scores in both groups were higher than before treatment (P < 0.05). The FDDQL score of treatment group was higher than that of control group (P < 0.05). After treatment, the levels of motilin and neuropeptide Y in two groups were higher than before treatment (P < 0.05). After treatment, motilin and neuropeptide Y levels in treatment group were higher than those in control group (P < 0.05). Conclusions Shenqu Xiaoshi Oral Liquid combined with lacidophilin has good clinical efficacy in treatment of functional dyspepsia in children, and can improve the TCM symptoms, life quality and digestive function of children, increase their appetite, which has no obvious adverse reactions.

R975

首都卫生发展科研专项（首发2020-3-7033）