目的 探讨心脉通胶囊联合瑞舒伐他汀钙片治疗老年高脂血症的临床疗效。方法 选取2021年5月—2023年6月淮南东方医院集团总医院收治的82例老年高脂血症患者，将所有患者根据随机数字表法分为对照组和治疗组，每组各41例。对照组口服瑞舒伐他汀钙片，1片/次，1次/d。治疗组在对照组基础上口服心脉通胶囊，4粒/次，3次/d。两组患者持续治疗12周。比较两组的治疗效果、血脂指标、血液流变学、血清指标。结果 治疗后，治疗组的总有效率为95.12%，对照组的总有效率为80.49%，组间比较差异显著（P＜0.05）。治疗后，两组的高密度脂蛋白胆固醇（HDL-C）比治疗前大，低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、总胆固醇（TC）比治疗前小（P＜0.05）；治疗组的HDL-C比对照组大，LDL-C、TG、TC比对照组小（P＜0.05）。治疗后，两组的红细胞比容（HCT）、纤维蛋白原（FIB）、血浆黏度（PV）均比治疗前小（P＜0.05）；治疗组的HCT、FIB、PV比对照组小（P＜0.05）。治疗后，两组的血清同型半胱氨酸（Hcy）、血管细胞黏附分子-1（VCAM-1）水平显著减小，血清脂联素（ADPN）水平显著增大（P＜0.05）；治疗组的血清Hcy、VCAM-1水平比对照组小，血清ADPN水平比对照组大（P＜0.05）。结论 心脉通胶囊联合瑞舒伐他汀钙片可提高老年高脂血症的治疗效果，显著改善血脂水平，改善血液流变学，有助于降低炎症反应。

Objective To explore the curative effect of Xinmaitong Capsules combined with Rosuvastatin Calcium Tablets in treatment of senile hyperlipidemia. Methods Patients (82 cases) with senile hyperlipidemia in Huainan Oriental Hospital Group General Hospital from May 2021 to June 2023 were divided into control and treatment groups according to the random number table method, and each group had 41 cases. Patients in the control group were po administered with Rosuvastatin Calcium Tablets, 1 tablet/time, once daily. Patients in the treatment group were po administered with Xinmaitong Capsules on the basis of the control group, 4 grains/time, three times daily. Patients in two groups were treated for 12 weeks. The clinical efficacies, the blood lipid indicators, hemorheology, and serum indicators in two groups were compared. Results After treatment, the total effective rate of the treatment group was 95.12%, while the total effective rate of the control group was 80.49%, with a significant difference between the groups (P < 0.05). After treatment, HDL-C in two groups was higher than before treatment, but LDL-C, TG, and TC in two groups were lower than before treatment (P < 0.05). HDL-C in the treatment group was higher than that in the control group, but LDL-C, TG, and TC in the treatment group were lower than that in the control group (P < 0.05). After treatment, HCT, FIB, and PV in two groups were lower than those before treatment (P < 0.05), and HCT, FIB, and PV in the treatment group were lower than those in the control group (P < 0.05). After treatment, the serum levels of Hcy and VCAM-1 in two groups were significantly decreased, while the serum levels of ADPN in two groups were significantly increased (P < 0.05). The serum levels of Hcy and VCAM-1 in the treatment group were lower than those in the control group, but the serum levels of ADPN were higher than those in the control group (P < 0.05). Conclusion Xinmaitong Capsules combined with Rosuvastatin Calcium Tablets can improve the therapeutic effect of senile hyperlipidemia, significantly improve blood lipid level, improve hemorheology, and help reduce inflammation.

R973

安徽省卫生健康委科研项目（AHWJ2021a037）