目的 探讨稳心颗粒联合盐酸维拉帕米注射液治疗阵发性室上性心动过速的临床疗效。方法 选取2021年7月—2023年6月在首都医科大学附属北京康复医院就诊的116例阵发性室上性心动过速患者，按随机数字表法分为对照组和治疗组，每组各58例。对照组静脉推注盐酸维拉帕米注射液，将5 mg盐酸维拉帕米注射液加入10 mL生理盐水，3 min内静脉推注，观察20 min，若病情未好转，重复注射直至转复后停止，每日剂量不超过50 mg。治疗组在对照组治疗基础上开水冲服稳心颗粒，1袋/次，3次/d。两组疗程均为4周。比较两组的临床疗效、发作和治疗情况、超声心电图检查和心功能指标。结果 治疗组的总有效率为93.10%，明显高于对照组的总有效率79.31%，差异有统计学意义（P＜0.05）。治疗后，治疗组的发作频次、平均转复时间低于治疗前，30 min内转复率高于治疗前（P＜0.05）；治疗组的发作频次、平均转复时间低于对照组，30 min内转复率高于对照组（P＜0.05）。治疗后，治疗组患者的短阵室速数、室性期前收缩数比治疗前小（P＜0.05），且比对照组的短阵室速数、室性期前收缩数更小（P＜0.05）。治疗后，治疗组的左心室射血分数（LVEF）比治疗前大，左心室收缩末期容积（LVESV）比治疗前小（P＜0.05）；治疗组患者的LVEF比对照组大，LVESV比对照组小（P＜0.05）。结论 稳心颗粒联合盐酸维拉帕米注射液可提高阵发性室上性心动过速的临床疗效，减轻发作频率，改善心功能。

Objective To investigate the effect of Wenxin Granules combined with Verapamil Hydrochloride Injection in treatment of paroxysmal supraventricular tachycardia. Methods Patients (116 cases) with paroxysmal supraventricular tachycardia in Beijing Rehabilitation Hospital Affiliated to Capital Medical University from July 2021 to June 2023 were divided into control and treatment groups according to the random number table method, and each group had 58 cases. Patients in the control group were iv administered with Verapamil Hydrochloride Injection, 5 mg drug added into normal saline 10 mL, iv within 3 min, observing for 20 min. If the condition did not improve, repeating the injection until recovery and stop. The daily dose did not exceed 50 mg. Patients in the treatment group were po administered with Wenxin Granules with boiling water on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, attack and treatment status, ultrasound electrocardiogram examination, and cardiac function indicators in two groups were compared. Results The total effective rate of the treatment group was 93.10%, which was significantly higher than 79.31% of the control group, and the difference was statistically significant (P < 0.05). After treatment, the attack frequency and average recovery time in the treatment group were lower than those before treatment, but the recovery rate within 30 min in the treatment group was higher than that before treatment (P < 0.05). The frequency of attack and the mean recovery time of treatment group were lower than that of control group, but the recovery rate within 30 min of treatment group was higher than that of control group (P < 0.05). After treatment, the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those before treatment (P < 0.05), and the number of short ventricular tachycles and the number of pre-ventricular contractions in the treatment group was smaller than those in the control group (P < 0.05). After treatment, LVEF in two groups were significantly higher than those before treatment, but LVESV was significantly decreased (P < 0.05). After treatment, LVEF in the treatment group were higher than those before treatment, but LVESV in the treatment group were lower than those in the control group (P < 0.05). Conclusion Wenxin Granule combined with Verapamil Hydrochloride Injection can improve the therapeutic effect of paroxysmal supraventricular tachycardia, reduce the frequency of attacks, and improve cardiac function.

R972

首都卫生发展科研专项项目（2022-3-2254）