目的 基于网络药理学方法和分子对接技术探究心可舒片治疗高血压的作用机制。方法 利用TCMSP、HERB、ETCM数据库和Swiss Target Prediction平台检索心可舒片的活性成分及作用靶点；通过OMIM、GeneCards、TTD和DrugBank数据库获取高血压的相关靶点。筛选出药物与疾病的交集靶点，通过Cytoscape 3.7.2软件和STRING数据库分别构建“中药–活性成分–靶点–疾病”及蛋白相互作用（PPI）网络并筛选出关键活性成分和核心靶点。运用DAVID数据库进行基因本体（GO）及京都基因与基因组百科全书（KEGG）通路富集分析，利用AutoDockTools软件进行分子对接验证。结果 共获得心可舒片活性成分147个，药物与疾病的交集靶点262个。心可舒片治疗高血压的关键活性成分为丹参醇A、香紫苏醇、三裂鼠尾草素等；核心靶点为原癌基因酪氨酸蛋白激酶Src（SRC）、肿瘤坏死因子（TNF）、信号转导和转录激活因子3（STAT3）等。GO富集分析涉及238个生物学过程，41个细胞组分，81个分子功能。KEGG富集分析涉及131条信号通路，包括钙信号通路、神经活性配体-受体相互作用、糖尿病并发症晚期糖基化终产物（AGE）及其受体（RAGE）信号通路等。分子对接显示关键活性成分与核心靶点之间有良好的结合活性。结论 心可舒片可通过多成分、多靶点、多途径发挥对高血压的治疗作用，为临床应用提供依据。

Objective To explore the mechanism of Xinkeshu Tablets in treatment of hypertension based on network pharmacology and molecular docking. Methods The active ingredients and targets of Xinkeshu Tablets were retrieved by TCMSP, HERB, ETCM Database and Swiss Target Prediction Platform. The relevant targets of hypertension were obtained from OMIM, GeneCards, TTD and DrugBank database. Screening out the common targets of drug and disease, the “traditional Chinese medicine–active ingredient–target–disease” and protein-protein interaction (PPI) network was constructed through Cytoscape 3.7.2 software and STRING database respectively, then the key active ingredients and core targets were screened out. Gene ontology (GO) analysis and kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis was carried out with the help of DAVID database, molecular docking verification was performed by using AutoDockTools software. Results A total of 147 active ingredients of Xinkeshu Tablets were collected, 262 common targets between drug and disease were obtained. Among them, the key active ingredients of Xinkeshu Tablets in treatment of hypertension were danshenol, sclareol, salvigenin etc. The core targets were SRC, TNF, STAT3 etc. GO enrichment analysis involved 238 biological processes, 41 cellular components and 81 molecular functions. KEGG enrichment analysis involved 131 signaling pathways including calcium signaling pathway, neuroactive ligand-receptor interaction, AGE-RAGE signaling pathway in diabetic complications etc. The molecular docking results showed that the key active ingredients exhibit good binding activity with core targets. Conclusion Xinkeshu Tablets may exert therapeutic effect on hypertension through multiple components, multiple targets and multiple pathways, providing a basis for clinical application.

R285；R286.2