目的 探讨重组牛碱性成纤维细胞生长因子眼用凝胶联合地夸磷索钠滴眼液治疗白内障术后干眼症的临床疗效。方法 选取2022年7月-2023年7月沧州市眼科医院收治的60例白内障术后干眼症患者,随机分为对照组(30例)和治疗组(30例)。对照组患者眼部滴注地夸磷索钠滴眼液,1~2滴/次,4次/d。在对照组基础上,治疗组涂抹重组牛碱性成纤维细胞生长因子眼用凝胶,2次/d。两组患者治疗7 d。观察两组患者临床疗效,比较治疗前后两组患者缓解症状时间,眼表荧光素染色(FL)和眼表疾病指数(OSDI)评分,及血清白细胞介素-1β(IL-1β)、丙二醇(MDA)、肿瘤坏死因子-α(TNF-α)和超氧化物歧化酶(SOD)水平。结果 治疗后,治疗组临床总有效率为96.67%,明显高于对照组(73.33%,P<0.05)。治疗后,治疗组症状好转时间均明显早于对照组(P<0.05)。治疗后,两组患者FL、OSDI评分比治疗前明显下降(P<0.05),且治疗组患者下降更明显(P<0.05)。治疗后,两组患者血清IL-1β、TNF-α和MDA水平明显降低,而SOD水平明显升高(P<0.05),且治疗组患者血清因子水平明显好于对照组(P<0.05)。结论 重组牛碱性成纤维细胞生长因子眼用凝胶与地夸磷索钠滴眼液协同治疗,可有效恢复临床症状,改善眼部炎性反应状态。

Objective To explore the clinical curative effect of Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel combined with Diquafosol Sodium Eye Drops in treatment of dry eye after cataract surgery. Methods Patients (60 cases) with dry eye after cataract surgery in Cangzhou Eye Hospital from July 2022 to July 2023 were randomly divided into control (30 cases) and treatment (30 cases) group. Patients in the control group were administered with Diquafosol Sodium Eye Drops, 1-2 drops/time, four times daily. Patients in the treatment group were administered with Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel on the basis of the control group, twice daily. Patients in two groups were treated for 7 d. After treatment, the clinical evaluations were evaluated, the symptom relief time, the scores FL and OSDI, and the levels of serum IL-1β, TNF-α, MDA and SOD in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 96.67%, which was significantly higher than that of the control group (73.33%, P < 0.05). After treatment, the time of symptom improvement in the treatment group was significantly earlier than that in the control group (P < 0.05). After treatment, the scores of FL and OSDI in two groups were significantly lower than those before treatment (P < 0.05), especially in the treatment group (P < 0.05). After treatment, the serum levels of IL-1β, TNF-α and MDA in two groups decreased significantly, while the level of SOD was significantly increased (P < 0.05), and the level of serum factors in the treatment group was significantly better than that in the control group (P < 0.05). Conclusion The combination of Recombinant Bovine Basic Fibroblast Growth Factor Eye-Gel and Diquafosol Sodium Eye Drops can effectively restore clinical symptoms and improve the state of ocular inflammatory reaction.

R988.1

河北省卫生健康委医学科学研究课题计划项目（20200343）