目的 探讨虎力散胶囊联合双醋瑞因胶囊治疗膝骨性关节炎的疗效。方法 选取唐山市人民医院在2021年2月-2023年1月收治的104例膝骨性关节炎患者,按照随机数字表法将所有患者分为对照组(52例)和治疗组(52例)。对照组口服双醋瑞因胶囊,1粒/次,2次/d。治疗组在对照组基础上口服虎力散胶囊,1粒/次,2次/d。两组患者持续4周。比较两组的临床疗效、患侧症状、关节功能和血清指标。结果 治疗组的总有效率为92.31%,对照组的总有效率为76.92%,组间比较差异显著(P<0.05)。治疗后,两组的数字疼痛量表(NRS)评分、晨僵时间、骨关节炎指数(WOMAC)评分以及血清血小板反应蛋白-1(TSP-1)、白细胞介素(IL)-15、葡萄糖-6-磷酸异构酶(GPI)水平低于治疗前(P<0.05),且治疗组各指标均比对照组低(P<0.05)。结论 膝骨性关节炎经虎力散胶囊联合双醋瑞因胶囊治疗,临床疗效进一步提高,患者临床症状明显减轻,膝关节功能明显好转,炎症损伤得到减轻。

Objective To investigate the therapeutic effect of Hulisan Capsules combined with Diacerein Capsules in treatment of knee osteoarthritis. Methods Patients (104 cases) with knee osteoarthritis in Tangshan People's Hospital from February 2021 to January 2023 were divided into control group (52 case) and treatment group (52 case) according to the random number table method. Patients in the control group were po administered with Diacerein Capsules, 1 grain/time, twice daily. Patients in the treatment group were po administered with Hulisan Capsules on the basis of the control group, 1 grain/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacies, symptoms on the affected side, joint function, and serum indicators in two groups were compared. Results After treatment, the total effective rate was 92.31% in the treatment group, and 76.92% in the control group, and the difference between the two groups was significant (P < 0.05). After treatment, the NRS score, morning rigor time, the WOMAC score, and the serum levels of TSP-1, IL-15, and GPI of two groups were lower than before treatment (P < 0.05), and the indexes of the treatment group were lower than those of the control group (P < 0.05). Conclusion The clinical efficacy of treating knee osteoarthritis with the combination of Hulisan Capsules and Diacerein Capsules has been further improved, the patient's clinical symptoms have significantly alleviated, knee joint function has significantly improved, and inflammatory damage has been alleviated.<

R982

河北省卫生健康委科研基金项目（20211110）