目的 观察普乐安胶囊联合盐酸坦索罗辛缓释胶囊治疗慢性前列腺炎的临床疗效。方法 选取2020年4月-2022年5月郑州大学第五附属医院收治的200例慢性前列腺炎患者,按照随机数字表法将所有患者分为对照组(100例)和治疗组(100例)。对照组饭后口服盐酸坦索罗辛缓释胶囊,1粒/次,1次/d。治疗组在对照组治疗的基础上口服普乐安胶囊,4~6粒/次,3次/d。两组均治疗2周。比较两组临床疗效、病情改善状况、尿流动力学指标、前列腺液细胞因子。结果 治疗后,治疗组的总有效率为96.00%,高于对照组总有效率85.00%(P<0.05)。治疗后,两组美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、国际前列腺症状评分表(IPSS)评分均显著下降,残余尿量减少,平均尿流率(Q_ave)、最大尿流率(Q_max)升高,前列腺液白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、前列腺素E₂(PGE₂)、白细胞介素-8(IL-8)、白细胞介素-12(IL-12)水平均显著下降(P<0.05),且治疗组病情改善状况、尿流动力学指标、前列腺液细胞因子均显著优于对照组(P<0.05)。结论 普乐安胶囊联合盐酸坦索罗辛缓释胶囊治疗慢性前列腺炎可有效改善患者临床症状和尿流动力学,减轻炎症反应。

Objective To observe the clinical efficacy of Pulean Capsules combine with Tamsulosin Hydrochloride Sustained-release Capsules in treatment of chronic prostatitis. Methods Patients (200 cases) with chronic prostatitis in the Fifth Affiliated Hospital of Zhengzhou University from April 2020 to May 2022 were divided into control group (100 cases) and treatment group (100 cases) according to the random number table method. Patients in the control group were po administered with Tamsulosin Hydrochloride Sustained-release Capsules, 1 grain/time, once daily. Patients in the treatment group were po administered with Pulean Capsules on the basis of the control group, 4-6 grains/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies, the improvement in condition, urodynamic indicators, and prostate fluid cytokines in two groups were compared. Results After treatment, the total effective rate of the treatment group was 96.00%, which was higher than the total effective rate of the control group of 85.00% (P < 0.05). After treatment, NIH-CPSI scores and IPSS scores of two groups were significantly decreased, the residual urine volume were decreased, but the Q_ave and Q_max were increased, the levels of IL-6, TNF-α, PGE₂, IL-8, and IL-12 in prostatic fluid of two groups were significantly decreased (P < 0.05), and the improvement in condition, urodynamic indicators, and prostate fluid cytokines of the treatment group were significantly better than those of the control group (P < 0.05). Conclusion Pulean Capsules combine with Tamsulosin Hydrochloride Sustained-release Capsules in treatment of chronic prostatitis, which can effectively improve the clinical symptoms of patients, reduce levels of inflammatory factors, and improve urodynamics.

R983

河南省高等学校重点科研项目计划（21A320037）